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Descriptor English: Dantrolene
Descriptor Spanish: Dantroleno
Descriptor dantroleno
Scope note: Relajante del músculo esquelético, que actúa interfiriendo en el acoplamiento excitación-contracción en la fibra muscular. Se utiliza para tratar la espasticidad y otros trastornos neuromusculares. Aunque el mecanismo de acción probablemente no es central, el dantroleno se incluye en el grupo de relajantes musculares centrales.
Descriptor Portuguese: Dantroleno
Descriptor French: Dantrolène
Entry term(s): Dantrium
Dantrolene Sodium
Sodium, Dantrolene
Tree number(s): D03.383.129.308.432.555.287
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003620
Scope note: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Muscle Relaxants, Central
Registry Number: F64QU97QCR
CAS Type 1 Name: 2,4-Imidazolidinedione, 1-(((5-(4-nitrophenyl)-2-furanyl)methylene)amino)-
Previous Indexing: Hydantoins (1966-1974)
Public MeSH Note: 80; was see under HYDANTOINS 1975-79
History Note: 80(75); was see under HYDANTOINS 1975-79
DeCS ID: 3639
Unique ID: D003620
NLM Classification: QV 140
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1980/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/28
Dantrolene - Preferred
Concept UI M0005658
Scope note Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
Preferred term Dantrolene
Dantrolene Sodium - Narrower
Concept UI M0005659
Preferred term Dantrolene Sodium
Entry term(s) Sodium, Dantrolene
Dantrium - Narrower
Concept UI M0005657
Preferred term Dantrium



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