| Descriptor English: | Alexander Disease | ||||
| Descriptor Spanish: |
Enfermedad de Alexander
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| Descriptor Portuguese: | Doença de Alexander | ||||
| Descriptor French: | Maladie d'Alexander | ||||
| Entry term(s): |
Alexander's Disease Alexanders Disease Demyelinogenic Leukodystrophy Dysmyelinogenic Leukodystrophy Fibrinoid Degeneration of Astrocytes Leukodystrophy with Rosenthal Fibers |
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| Tree number(s): |
C10.228.140.163.100.362.312 C10.228.140.695.625.312 C10.314.400.312 C10.574.500.024 C16.320.400.024 C16.320.565.189.362.312 C18.452.132.100.362.312 C18.452.648.189.362.312 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D038261 | ||||
| Scope note: | Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance. |
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| Allowable Qualifiers: |
BL blood CF cerebrospinal fluid CI chemically induced CL classification CO complications DG diagnostic imaging DH diet therapy DI diagnosis DT drug therapy EC economics EH ethnology EM embryology EN enzymology EP epidemiology ET etiology GE genetics HI history IM immunology ME metabolism MI microbiology MO mortality NU nursing PA pathology PC prevention & control PP physiopathology PS parasitology PX psychology RH rehabilitation RT radiotherapy SU surgery TH therapy UR urine VE veterinary VI virology |
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| Public MeSH Note: | 2003 |
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| History Note: | 2003 |
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| Related: |
Glial Fibrillary Acidic Protein
MeSH | ||||
| DeCS ID: | 37281 | ||||
| Unique ID: | D038261 | ||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||
| Date Established: | 2003/01/01 | ||||
| Date of Entry: | 2002/07/02 | ||||
| Revision Date: | 2013/07/08 |
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Alexander Disease
- Preferred
| Concept UI |
M0415670 |
| Scope note | Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance. |
| Preferred term | Alexander Disease |
| Entry term(s) |
Alexander's Disease Alexanders Disease Demyelinogenic Leukodystrophy Dysmyelinogenic Leukodystrophy Fibrinoid Degeneration of Astrocytes Leukodystrophy with Rosenthal Fibers |
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