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Descriptor in English: Aristolochic Acids
Descriptor in Spanish: Ácidos Aristolóquicos
Descriptor in Portuguese: Ácidos Aristolóquicos
Descriptor in French: Acides aristolochiques
Tree number(s): D02.455.426.559.847.723.089
D02.640.139
D04.615.723.089
Scope note: Nitro-phenanthrenes occurring in ARISTOLOCHIACEAE and other plants. They derive from stephanine (APORPHINES) by oxidative ring cleavage. The nitro group is a reactive alkylator (ALKYLATING AGENTS) that binds to biological macromolecules. Ingestion by humans is associated with nephropathy (NEPHRITIS). There is no relationship to the similar named aristolochene (SESQUITERPENES).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 2003
DeCS UI: 37310
Descriptor UI: D034341
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2009/08/20
Aristolochic Acids - Preferred
Concept UI M0405368
Scope note Nitro-phenanthrenes occurring in ARISTOLOCHIACEAE and other plants. They derive from stephanine (APORPHINES) by oxidative ring cleavage. The nitro group is a reactive alkylator (ALKYLATING AGENTS) that binds to biological macromolecules. Ingestion by humans is associated with nephropathy (NEPHRITIS). There is no relationship to the similar named aristolochene (SESQUITERPENES).
Preferred term Aristolochic Acids



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