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Descriptor English: Receptor, EphA1
Descriptor Spanish: Receptor EphA1
Descriptor receptor EphA1
Scope note: Miembro fundador de la familia de receptores Eph. Fue primeramente clonado de una línea celular de carcinoma hepatocelular humano, productora de eritropoyetina y ampliamente conservado entre las muchas especies de mamíferos. La sobreproducción del receptor EphA1 se asocia a tumores y células tumorales de origen epitelial. También se manifiesta en altas concentraciones en el HIGADO, PULMÓN y RIÑÓN, en contraste con los otros muchos miembros del receptor Eph que se encuentran sobre todo en tejidos del sistema nervioso.
Descriptor Portuguese: Receptor EphA1
Descriptor French: Récepteur EphA1
Entry term(s): EPHA1 Protein
EPHA1 Receptor Tyrosine Kinase
Eph Receptor
EphA1 Receptor
Tree number(s): D08.811.913.696.620.682.725.400.850.050
D12.776.476.568.400.850.050
D12.776.543.750.630.500.050
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D036082
Scope note: The founding member of the EPH FAMILY RECEPTORS. It was first cloned from an erythropoietin-producing human hepatocellular carcinoma cell line and is highly conserved among many mammalian species. Overproduction of the EphA1 receptor is associated with tumors and tumor cells of epithelial origin. It is also expressed at high levels in LIVER; LUNG; and KIDNEY; which is in contrast to many other members of the Eph receptor that are found primarily in tissues of the nervous system.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.10.1
Previous Indexing: Receptor Protein-Tyrosine Kinases (1999-2002)
Public MeSH Note: 2003; EPHA1 PROTEIN (now RECEPTOR, EPHA1) were indexed under RECEPTOR PROTEIN-TYROSINE KINASES 1999-2002
History Note: 2003; use RECEPTOR, EPHA1 (NM) 1999-2002
Entry Version: RECEPT EPHA1
DeCS ID: 37344
Unique ID: D036082
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2016/05/31
Receptor, EphA1 - Preferred
Concept UI M0333628
Scope note The founding member of the EPH FAMILY RECEPTORS. It was first cloned from an erythropoietin-producing human hepatocellular carcinoma cell line and is highly conserved among many mammalian species. Overproduction of the EphA1 receptor is associated with tumors and tumor cells of epithelial origin. It is also expressed at high levels in LIVER; LUNG; and KIDNEY; which is in contrast to many other members of the Eph receptor that are found primarily in tissues of the nervous system.
Preferred term Receptor, EphA1
Entry term(s) EPHA1 Protein
EPHA1 Receptor Tyrosine Kinase
Eph Receptor
EphA1 Receptor



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