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Descriptor English: Semaphorin-3A
Descriptor Spanish: Semaforina-3A
Descriptor semaforina-3A
Scope note: El miembro prototípico y mejor estudiado de la familia de las semaforinas. La semaforina-3A es una señal guía de repulsión axónica en relación con las neuronas migratorias del sistema nervioso en desarrollo. Hasta el momento se ha encontrado sólo en vertebrados y se une a los receptores del complejo NEUROPILINA-1/plexina en los conos de crecimiento. Al igual que otras semaforinas de clase 3, es una proteína segregada.
Descriptor Portuguese: Semaforina-3A
Descriptor French: Sémaphorine-3A
Entry term(s): Collapsin
Collapsin 1
Collapsin-1
Collapsing Factor
Sem D
Sema3A
Semaphorin 3A
Semaphorin D
Tree number(s): D12.644.276.923.374
D12.776.467.923.374
D23.529.923.374
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D040121
Scope note: The prototypical and most well-studied member of the semaphorin family. Semaphorin-3A is an axon-repulsive guidance cue for migrating neurons in the developing nervous system. It has so far been found only in vertebrates, and binds to NEUROPILIN-1/plexin complex receptors on growth cones. Like other class 3 semaphorins, it is a secreted protein.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Glycoproteins (1993-2002)
Public MeSH Note: 2003; COLLAPSIN (now SEMAPHORIN 3A) was indexed under GLYCOPROTEINS 1993-2002
History Note: 2003; use SEMAPHORIN 3A (NM) 1994-2002
DeCS ID: 37455
Unique ID: D040121
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2013/07/09
Semaphorin-3A - Preferred
Concept UI M0222872
Scope note The prototypical and most well-studied member of the semaphorin family. Semaphorin-3A is an axon-repulsive guidance cue for migrating neurons in the developing nervous system. It has so far been found only in vertebrates, and binds to NEUROPILIN-1/plexin complex receptors on growth cones. Like other class 3 semaphorins, it is a secreted protein.
Preferred term Semaphorin-3A
Entry term(s) Collapsin
Collapsin 1
Collapsin-1
Collapsing Factor
Sem D
Sema3A
Semaphorin 3A
Semaphorin D



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