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Descriptor English: Semaphorins
Descriptor Spanish: Semaforinas
Descriptor semaforinas
Scope note: Familia de proteínas que median la GUÍA AXONAL. Las semaforinas actúan como señales repulsivas para los CONOS DE CRECIMIENTO neuronales y se unen a receptores de sus filopodios. Se han descrito más de 20 moléculas diferentes que se dividen en ocho clases basadas en la organización de los dominios y las especies de origen. Las clases 1 y 2 son de los invertebrados, las clases 3-7 son de los vertebrados y la clase V pertenece a los virus. Las semaforinas pueden ser secretadas (clases 2, 3 y V), transmembranarias (clases 1, 4, 5 y 6), o ancladas a la membrana (clase 7). Todas las semaforinas poseen un dominio extracelular de 500 aminoácidos común que es crítico para la unión al receptor y la especificidad, y se encuentran también en plexinas y receptores del factor de dispersión. Sus terminales C son específicos de la clase y pueden contener motivos de secuencias adicionales.
Descriptor Portuguese: Semaforinas
Descriptor French: Sémaphorines
Entry term(s): Class 1 Semaphorins
Class 2 Semaphorins
Class 3 Semaphorins
Class 4 Semaphorins
Class 5 Semaphorins
Class 6 Semaphorins
Class 7 Semaphorins
Class V Semaphorins
Sema 1
Semaphorin
Semaphorin 1
Semaphorin 2
Semaphorin 3
Semaphorin 4
Semaphorin 5
Semaphorin 6
Semaphorin 7
Semaphorin V
Semaphorin-1
Semaphorin-2
Semaphorin-3
Semaphorin-4
Semaphorin-5
Semaphorin-6
Semaphorin-7
Semaphorin-V
Semaphorins, Class 1
Semaphorins, Class 2
Semaphorins, Class 3
Semaphorins, Class 4
Semaphorins, Class 5
Semaphorins, Class 6
Semaphorins, Class 7
Semaphorins, Class V
Tree number(s): D12.644.276.923
D12.776.467.923
D23.529.923
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D039961
Scope note: A family of proteins that mediate AXONAL GUIDANCE. Semaphorins act as repulsive cues for neuronal GROWTH CONES and bind to receptors on their filopodia. At least 20 different molecules have been described and divided into eight classes based on domain organization and species of origin. Classes 1 and 2 are invertebrate, classes 3-7 are vertebrate, and class V are viral. Semaphorins may be secreted (classes 2, 3, and V), transmembrane (classes 1, 4, 5, and 6), or membrane-anchored (class 7). All semaphorins possess a common 500-amino acid extracellular domain which is critical for receptor binding and specificity, and is also found in plexins and scatter factor receptors. Their C termini are class-specific and may contain additional sequence motifs.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Public MeSH Note: 2003; SEMA 1 & SEMAPHORIN-1 was indexed under CELL ADHESION MOLECULES, NEURONAL 1994-2002
History Note: 2003; for SEMA 1 & SEMAPHORIN-1 use SEMAPHORIN 1A, GRASSHOPPER (NM) 1994-2002
DeCS ID: 37454
Unique ID: D039961
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2016/02/26
Semaphorins - Preferred
Concept UI M0419969
Scope note A family of proteins that mediate AXONAL GUIDANCE. Semaphorins act as repulsive cues for neuronal GROWTH CONES and bind to receptors on their filopodia. At least 20 different molecules have been described and divided into eight classes based on domain organization and species of origin. Classes 1 and 2 are invertebrate, classes 3-7 are vertebrate, and class V are viral. Semaphorins may be secreted (classes 2, 3, and V), transmembrane (classes 1, 4, 5, and 6), or membrane-anchored (class 7). All semaphorins possess a common 500-amino acid extracellular domain which is critical for receptor binding and specificity, and is also found in plexins and scatter factor receptors. Their C termini are class-specific and may contain additional sequence motifs.
Preferred term Semaphorins
Entry term(s) Semaphorin
Class 2 Semaphorins - Narrower
Concept UI M0421692
Preferred term Class 2 Semaphorins
Entry term(s) Semaphorin 2
Semaphorin-2
Semaphorins, Class 2
Class 3 Semaphorins - Narrower
Concept UI M0421693
Preferred term Class 3 Semaphorins
Entry term(s) Semaphorin 3
Semaphorin-3
Semaphorins, Class 3
Class V Semaphorins - Narrower
Concept UI M0421731
Preferred term Class V Semaphorins
Entry term(s) Semaphorin V
Semaphorin-V
Semaphorins, Class V
Class 5 Semaphorins - Narrower
Concept UI M0421695
Preferred term Class 5 Semaphorins
Entry term(s) Semaphorin 5
Semaphorin-5
Semaphorins, Class 5
Class 6 Semaphorins - Narrower
Concept UI M0421729
Preferred term Class 6 Semaphorins
Entry term(s) Semaphorin 6
Semaphorin-6
Semaphorins, Class 6
Class 7 Semaphorins - Narrower
Concept UI M0421730
Preferred term Class 7 Semaphorins
Entry term(s) Semaphorin 7
Semaphorin-7
Semaphorins, Class 7
Class 1 Semaphorins - Narrower
Concept UI M0209551
Scope note Transmembrane proteins involved in axonal guidance of peripheral neurons in the developing CNS of invertebrates. Semaphorin-1 refers to the class of SEMAPHORINS with an extracellular sema domain and a short cytoplasmic domain. Sema-1 was first identified in grasshopper as fasciclin IV, and has since been described in Drosophila and C. elegans. Two distinct members of this class of semaphorins exist: SEMA-1a (the original sema-1) and SEMA-1b, a homologous protein isolated from Drosophila which may be more important for neuronal differentiation than migration.
Preferred term Class 1 Semaphorins
Entry term(s) Sema 1
Semaphorin 1
Semaphorin-1
Semaphorins, Class 1
Class 4 Semaphorins - Narrower
Concept UI M0421694
Preferred term Class 4 Semaphorins
Entry term(s) Semaphorin 4
Semaphorin-4
Semaphorins, Class 4



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