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Descriptor English: Phosphatidylinositol Diacylglycerol-Lyase
Descriptor Spanish: Fosfatidilinositol Diacilglicerol-Liasa
Descriptor fosfatidilinositol diacilglicerol-liasa
Entry term(s) 1-fosfatidilinositol fosfodiesterasa
Scope note: Liasa de fósforo-oxígeno que se encuentra principalmente en las BACTERIAS. Esta enzima cataliza la división de una unión fosfoéster en una molécula de 1-fosfatidil-1D-mioinositol para formar 1D-mioinositol 1,2-fosfato cíclico y diacilglicerol. La enzima fue clasificada antiguamente como diéster fosfórico hidrolasa (EC3.1.4.10) y a menudo se la denomina FOSFOLIPASA DE TIPO C. Sin embargo, actualmente se sabe que el fosfato cíclico es el producto final de esta enzima y que en la reacción no interviene el agua.
Descriptor Portuguese: Fosfatidilinositol Diacilglicerol-Liase
Descriptor French: Phosphatidylinositol Diacylglycerol-Lyase
Entry term(s): 1 Phosphatidylinositol Phosphodiesterase
1-Phosphatidylinositol Phosphodiesterase
Diacylglycerol-Lyase, Phosphatidylinositol
Monophosphatidylinositol Phosphodiesterase
Phosphatidylinositol Diacylglycerol Lyase
Phosphodiesterase, 1-Phosphatidylinositol
Phosphodiesterase, Monophosphatidylinositol
Tree number(s): D08.811.277.352.640.700.700.500
D08.811.520.650.800
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D043265
Scope note: A phosphorus-oxygen lyase found primarily in BACTERIA. The enzyme catalyzes the cleavage of a phosphoester linkage in 1-phosphatidyl-1D-myo-inositol to form 1D-myo-inositol 1,2-cyclic phosphate and diacylglycerol. The enzyme was formerly classified as a phosphoric diester hydrolase (EC 3.1.4.10) and is often referred to as a TYPE C PHOSPHOLIPASES. However it is now known that a cyclic phosphate is the final product of this enzyme and that water does not enter into the reaction.
Annotation: note X refs: TYPE C PHOSPHOLIPASES is also available
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 4.6.1.13
Previous Indexing: Phosphatidylinositols (1977-1982)
Phospholipase C (1998-2003)
Phosphoric Diester Hydrolases (1976-1997)
Public MeSH Note: 2004; 1-PHOSPHATYDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE C (now PHOSPHATIDYLINOSITOL DIACYLGLYCEROL-LYASE) was indexed under PHOSPHOLIPASE C 1998-2003; under PHOSPHORIC DIESTER HYDROLASES 1976-1997 & under PHOSPHATIDYLINOSITOLS 1977-1982
History Note: 2004; use PHOSPHOTIDYLINOSITOL DIACYLGLYCEROL-LYASE (NM) 1980-2003
DeCS ID: 38148
Unique ID: D043265
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2007/07/11
Phosphatidylinositol Diacylglycerol-Lyase - Preferred
Concept UI M0077159
Scope note A phosphorus-oxygen lyase found primarily in BACTERIA. The enzyme catalyzes the cleavage of a phosphoester linkage in 1-phosphatidyl-1D-myo-inositol to form 1D-myo-inositol 1,2-cyclic phosphate and diacylglycerol. The enzyme was formerly classified as a phosphoric diester hydrolase (EC 3.1.4.10) and is often referred to as a TYPE C PHOSPHOLIPASES. However it is now known that a cyclic phosphate is the final product of this enzyme and that water does not enter into the reaction.
Preferred term Phosphatidylinositol Diacylglycerol-Lyase
Entry term(s) 1 Phosphatidylinositol Phosphodiesterase
1-Phosphatidylinositol Phosphodiesterase
Diacylglycerol-Lyase, Phosphatidylinositol
Monophosphatidylinositol Phosphodiesterase
Phosphatidylinositol Diacylglycerol Lyase
Phosphodiesterase, 1-Phosphatidylinositol
Phosphodiesterase, Monophosphatidylinositol



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