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Descriptor English: Vascular Endothelial Growth Factor A
Descriptor Spanish: Factor A de Crecimiento Endotelial Vascular
Descriptor factor A de crecimiento endotelial vascular
Entry term(s) factor A de crecimiento del endotelio vascular
factor de crecimiento del endotelio vascular
factor de crecimiento endotelial vascular
factor de crecimiento endotelial vascular A
factor-A de crecimiento endotelial vascular
Scope note: El miembro original de la familia de los factores de crecimiento de la célula endotelial denominados FACTORES DE CRECIMIENTO ENDOTELIAL VASCULAR. El factor A de crecimiento endotelial vascular fue originalmente aislado de células tumorales y se le denominó 'factor de angiogénesis tumoral' y 'factor de permeabilidad vascular'. Aunque expresado en concentraciones elevadas en ciertas células derivadas de tumores, es producido por una amplia variedad de tipos celulares. Además de estimular el crecimiento y la permeabilidad vascular, puede tener un papel en la estimulación de la VASODILATACIÓN por vías dependientes del ÓXIDO NÍTRICO. El corte y empalme alternante del ARNm del factor A de crecimiento endotelial vascular da lugar a varias isoformas de la proteína que se produce.
Descriptor Portuguese: Fator A de Crescimento do Endotélio Vascular
Descriptor French: Facteur de croissance endothéliale vasculaire de type A
Entry term(s): GD-VEGF
Glioma Derived Vascular Endothelial Cell Growth Factor
Glioma-Derived Vascular Endothelial Cell Growth Factor
Permeability Factor, Vascular
VEGF
VEGF-A
Vascular Endothelial Growth Factor
Vascular Endothelial Growth Factor-A
Vascular Permeability Factor
Vasculotropin
Tree number(s): D12.644.276.100.800.200
D12.776.467.100.800.200
D23.529.100.800.200
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D042461
Scope note: The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Endothelial Growth Factors (2000-2003)
Public MeSH Note: 2004; VASCULAR ENDOTHELIAL GROWTH FACTOR was indexed under ENDOTHELIAL GROWTH FACTORS 2000-2002
History Note: 2004; use VASCULAR ENDOTHELIAL GROWTH FACTOR A (NM) 2000-2002
DeCS ID: 38244
Unique ID: D042461
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2013/07/09
Vascular Endothelial Growth Factor A - Preferred
Concept UI M0356369
Scope note The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Preferred term Vascular Endothelial Growth Factor A
Entry term(s) Permeability Factor, Vascular
VEGF
VEGF-A
Vascular Endothelial Growth Factor
Vascular Endothelial Growth Factor-A
Vascular Permeability Factor
Vasculotropin
Glioma-Derived Vascular Endothelial Cell Growth Factor - Narrower
Concept UI M0175398
Preferred term Glioma-Derived Vascular Endothelial Cell Growth Factor
Entry term(s) GD-VEGF
Glioma Derived Vascular Endothelial Cell Growth Factor



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