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Descriptor English: Chromosome Fragile Sites
Descriptor Spanish: Sitios Frágiles del Cromosoma
Descriptor sitios frágiles de los cromosomas
Entry term(s) sítios cromosómicos frágiles
sítios frágiles cromosómicos
Scope note: Loci específicos que se muestran durante la CARIOTIPIFICACIÓN como una brecha (tramo no condensado a mayor aumento) en un brazo de la CROMÁTIDE después de cultivar las células en condiciones específicas. Estos sitios se asocian con un aumento de la FRAGILIDAD CROMOSÓMICA. Se clasifican como frecuentes o raros, y según las condiciones específicas de cultivo en las que se desarrollan. Los loci de los sitios frágiles se denominan con las "FRA" seguidas por una designación del cromosoma específico y una letra que se refiere al sitio frágil de ese cromosoma (p. ej., FRAXA se refiere al sitio frágil A en el cromosoma X. Es un sitio frágil, raro y sensible al ácido fólico que se asocia al SÍNDROME DEL CROMOSOMA X FRÁGIL).
Descriptor Portuguese: Sítios Frágeis do Cromossomo
Descriptor French: Sites fragiles de chromosome
Entry term(s): Chromosome Fragile Site
Fragile Site, Chromosome
Fragile Sites, Chromosome
Site, Chromosome Fragile
Sites, Chromosome Fragile
Tree number(s): G05.360.340.024.189.610
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D043283
Scope note: Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Chromosome Fragility (1982-2003)
Public MeSH Note: 2004; see CHROMOSOME FRAGILITY 1982-2003
History Note: 2004; use CHROMOSOME FRAGILITY 1982-2003
Related: Chromosome Fragility MeSH
DNA Repeat Expansion MeSH
Fragile X Syndrome MeSH
DeCS ID: 38395
Unique ID: D043283
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2013/07/09
Chromosome Fragile Sites - Preferred
Concept UI M0004412
Scope note Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)
Preferred term Chromosome Fragile Sites
Entry term(s) Chromosome Fragile Site
Fragile Site, Chromosome
Fragile Sites, Chromosome
Site, Chromosome Fragile
Sites, Chromosome Fragile



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