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Descriptor English: Mitogen-Activated Protein Kinase 10
Descriptor Spanish: Proteína Quinasa 10 Activada por Mitógenos
Descriptor proteína cinasa activada por mitógenos 10
Entry term(s) proteína quinasa 10 activada por mitógenos
Scope note: Quinasa aminoterminal c-jun que se encuentra predominantemente en las NEURONAS del CEREBRO, lo que sugiere su intervención en la APOPTOSIS neuronal inducida por el estrés. Existen varias isoformas de la proteína, con tamaños moleculares de 47 y 52 kDa, debidas a EMPALME ALTERNATIVO múltiple.
Descriptor Portuguese: Proteína Quinase 10 Ativada por Mitógeno
Descriptor French: Mitogen-Activated Protein Kinase 10
Entry term(s): 3F12 Kinase, p49
JNK3 Mitogen Activated Protein Kinase
Kinase 3, c-jun
MAP Kinase p49(3F12)
MAPK10 Mitogen Activated Protein Kinase
MAPK10 Mitogen-Activated Protein Kinase
Mitogen Activated Protein Kinase 10
Mitogen Activated Protein Kinase p49(3F12)
Stress Activated Protein Kinase JNK3
Stress-Activated Protein Kinase JNK3
c jun Kinase 3
c jun N Terminal Kinase 3
c-jun Kinase 3
c-jun N-Terminal Kinase 3
p49 3F12 Kinase
p49(3F12) SAP Kinase
p54-SAPK(beta)
Tree number(s): D08.811.913.696.620.682.700.567.374.800
D12.776.476.563.567.374.800
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D048057
Scope note: A c-jun amino-terminal kinase that is found predominantly within NEURONS of the BRAIN, suggesting a role in stress-induced neuronal APOPTOSIS. Several isoforms of the protein with molecular sizes of 47 kDa and 52 kDa exist due to multiple ALTERNATIVE SPLICING.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.1.-
Previous Indexing: Mitogen-Activated Protein Kinases (2000-2004)
Protein-Serine-Threonine Kinases (1995-1999)
Public MeSH Note: 2005; MITOGEN-ACTIVATED PROTEIN KINASE 10 was indexed under MITOGEN-ACTIVATED PROTEIN KINASES 2000-2004, under PROTEIN-SERINE-THREONINE KINASES 1995-1999
History Note: 2005(1995)
DeCS ID: 38734
Unique ID: D048057
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2005/01/01
Date of Entry: 2004/07/07
Revision Date: 2015/11/24
Mitogen-Activated Protein Kinase 10 - Preferred
Concept UI M0241808
Scope note A c-jun amino-terminal kinase that is found predominantly within NEURONS of the BRAIN, suggesting a role in stress-induced neuronal APOPTOSIS. Several isoforms of the protein with molecular sizes of 47 kDa and 52 kDa exist due to multiple ALTERNATIVE SPLICING.
Preferred term Mitogen-Activated Protein Kinase 10
Entry term(s) 3F12 Kinase, p49
JNK3 Mitogen Activated Protein Kinase
Kinase 3, c-jun
MAP Kinase p49(3F12)
MAPK10 Mitogen Activated Protein Kinase
MAPK10 Mitogen-Activated Protein Kinase
Mitogen Activated Protein Kinase 10
Mitogen Activated Protein Kinase p49(3F12)
Stress Activated Protein Kinase JNK3
Stress-Activated Protein Kinase JNK3
c jun Kinase 3
c jun N Terminal Kinase 3
c-jun Kinase 3
c-jun N-Terminal Kinase 3
p49 3F12 Kinase
p49(3F12) SAP Kinase
p54-SAPK(beta)



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