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Descriptor English: Diphosphonates
Descriptor Spanish: Difosfonatos
Descriptor Portuguese: Difosfonatos
Descriptor French: Diphosphonates
Entry term(s): Bisphosphonate
Bisphosphonates
Tree number(s): D02.705.429.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004164
Scope note: Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Bone Density Conservation Agents
Previous Indexing: Organophosphorus Compounds (1971-1976)
Phosphonic Acids (1966-1976)
Public MeSH Note: 77
History Note: 77
DeCS ID: 4220
Unique ID: D004164
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1977/01/01
Date of Entry: 1976/04/16
Revision Date: 2020/05/27
Diphosphonates - Preferred
Concept UI M0006519
Scope note Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
Preferred term Diphosphonates
Entry term(s) Bisphosphonate
Bisphosphonates



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