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Descriptor in English: Diphosphonates
Descriptor in Spanish: Difosfonatos
Descriptor in Portuguese: Difosfonatos
Descriptor in French: Diphosphonates
Entry term(s): Bisphosphonates
Tree number(s): D02.705.429.500
Scope note: Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 77
DeCS UI: 4220
Descriptor UI: D004164
Date Established: 1977/01/01
Date of Entry: 1976/04/16
Revision Date: 2012/07/03
Diphosphonates - Preferred
Concept UI M0006519
Scope note Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
Preferred term Diphosphonates
Entry term(s) Bisphosphonates



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