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Descriptor English: Echinomycin
Descriptor Spanish: Equinomicina
Descriptor equinomicina
Entry term(s) quinomicina A
Scope note: Antibiótico quinoxalínico polipéptido citotóxico, aislado del Streptomyces echinatus que se une al ADN e inhibe la síntesis de ARN. Tiene actividad antitumoral y antibacteriana.
Descriptor Portuguese: Equinomicina
Descriptor French: Échinomycine
Entry term(s): NSC 526417
NSC-526417
NSC526417
Quinomycin A
Tree number(s): D03.633.100.857.233
D04.345.566.297.250
D12.644.641.297.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004448
Scope note: A cytotoxic polypeptide quinoxaline antibiotic isolated from Streptomyces echinatus that binds to DNA and inhibits RNA synthesis.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Bacterial Agents
Antibiotics, Antineoplastic
Nucleic Acid Synthesis Inhibitors
Registry Number: 512-64-1
CAS Type 1 Name: Quinomycin A
Previous Indexing: Antibiotics (1968-1975)
Peptides, Cyclic (1975)
Quinoxalines (1972-1975)
Public MeSH Note: 91; was see under QUINOXALINES 1976-90
History Note: 91(76); was see under QUINOXALINES 1976-90
DeCS ID: 4513
Unique ID: D004448
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1975/07/18
Revision Date: 2016/05/31
Echinomycin - Preferred
Concept UI M0006965
Scope note A cytotoxic polypeptide quinoxaline antibiotic isolated from Streptomyces echinatus that binds to DNA and inhibits RNA synthesis.
Preferred term Echinomycin
Entry term(s) Quinomycin A
NSC-526417 - Narrower
Concept UI M0373523
Preferred term NSC-526417
Entry term(s) NSC 526417
NSC526417



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