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Descriptor in English: Epidermal Growth Factor
Descriptor in Spanish: Factor de Crecimiento Epidérmico
Descriptor in Portuguese: Fator de Crescimento Epidérmico
Descriptor in French: Facteur de croissance épidermique
Entry term(s): EGF
Epidermal Growth Factor-Urogastrone
Growth Factor, Epidermal
Growth Factor-Urogastrone, Epidermal
Human Urinary Gastric Inhibitor
Urogastrone
beta Urogastrone
beta-Urogastrone
Tree number(s): D06.472.317.350
D12.644.276.382.500
D12.776.467.382.500
D23.529.382.500
Scope note: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 2000(1982); use PEPTIDES 1977-1981; for UROGASTRONE use GASTROINTESTINAL HORMONES 1963-1981
See also the descriptors: Anti-Ulcer Agents MeSH
ErbB Receptors MeSH
Gastrointestinal Agents MeSH
DeCS UI: 4896
Descriptor UI: D004815
Date Established: 1982/01/01
Date of Entry: 1976/04/16
Revision Date: 2018/07/02
Epidermal Growth Factor - Preferred
Concept UI M0007549
Scope note A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.
Preferred term Epidermal Growth Factor
Entry term(s) EGF
Epidermal Growth Factor-Urogastrone
Growth Factor, Epidermal
Growth Factor-Urogastrone, Epidermal
Human Urinary Gastric Inhibitor
Urogastrone
beta Urogastrone
beta-Urogastrone



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