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Descriptor English: Heparin-binding EGF-like Growth Factor
Descriptor Spanish: Factor de Crecimiento Similar a EGF de Unión a Heparina
Descriptor factor de crecimiento similar a EGF de unión a heparina
Entry term(s) HB-EGF
Scope note: Miembro de la familia del EGF que se expresa en diversas células hematopoyéticas, endoteliales, del músculo liso vascular y epiteliales. Es sintetizado como proteína transmembrana y escindida por proteasas, dando lugar a la forma secretora de la proteína, específica del RECEPTOR DE EGF Y ERBB-4. La forma proteínica rodeada de membrana ha sido identificada como el receptor que se une a la TOXINA DIFTÉRICA y permite su entrada en la célula.
Descriptor Portuguese: Fator de Crescimento Semelhante a EGF de Ligação à Heparina
Descriptor French: Facteur de croissance de type EGF liant l'héparine
Entry term(s): Diphtheria Toxin Receptor
Diphtheria Toxin Receptors
HB EGF
HB EGF Precursor
HB-EGF
HB-EGF Precursor
HB-EGF, Short Form
Heparin binding EGF like Growth Factor
Heparin binding Epidermal Growth Factor like Growth Factor Precursor Protein
Heparin-binding EGF-like Growth-Factor
Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein
Receptor, Diphtheria Toxin
Receptors, Diphtheria Toxin
SF HB EGF
SF HB-EGF
Short Form HB EGF
Short Form HB-EGF
Toxin Receptor, Diphtheria
Toxin Receptors, Diphtheria
Tree number(s): D12.644.276.382.625
D12.776.467.382.625
D23.529.382.625
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D066257
Scope note: An EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as a transmembrane protein which is cleaved by proteases to produce the secreted form of the protein which has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR. The membrane-bound form of the protein has been identified as the receptor which binds to and allows DIPHTHERIA TOXIN to enter cells.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Public MeSH Note: 2015; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR was indexed under INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS 2008-2014, and under EPIDERMAL GROWTH FACTOR 1992-2007
History Note: 2015
DeCS ID: 55622
Unique ID: D066257
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2015/01/01
Date of Entry: 2014/06/26
Revision Date: 2014/06/24
Heparin-binding EGF-like Growth Factor - Preferred
Concept UI M0593431
Scope note An EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as a transmembrane protein which is cleaved by proteases to produce the secreted form of the protein which has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR. The membrane-bound form of the protein has been identified as the receptor which binds to and allows DIPHTHERIA TOXIN to enter cells.
Preferred term Heparin-binding EGF-like Growth Factor
Entry term(s) HB EGF
HB-EGF
Heparin binding EGF like Growth Factor
Heparin-binding EGF-like Growth-Factor
Short Form HB-EGF - Narrower
Concept UI M0434129
Preferred term Short Form HB-EGF
Entry term(s) HB-EGF, Short Form
SF HB EGF
SF HB-EGF
Short Form HB EGF
Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein - Narrower
Concept UI M0514599
Preferred term Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein
Entry term(s) Diphtheria Toxin Receptor
Diphtheria Toxin Receptors
HB EGF Precursor
HB-EGF Precursor
Heparin binding Epidermal Growth Factor like Growth Factor Precursor Protein
Receptor, Diphtheria Toxin
Receptors, Diphtheria Toxin
Toxin Receptor, Diphtheria
Toxin Receptors, Diphtheria



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