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Descriptor English: STAT5 Transcription Factor
Descriptor Spanish: Factor de Transcripción STAT5
Descriptor factor de transcripción STAT5
Scope note: Transductor de señales y activador de la transcripción que media en las respuestas celulares a diversas CITOCINAS. La activación de Stat5 se asocia a la transcripción de reguladores del CICLO CELULAR, como el INHIBIDOR P21 DE CICLINA-CINASA y de genes antiapoptósicos tales como los GENES BCL-2. Stat5 se activa constitutivamente en muchos pacientes con LEUCEMIA MIELOIDE aguda.
Descriptor Portuguese: Fator de Transcrição STAT5
Descriptor French: Facteur de transcription STAT-5
Entry term(s): Factor, STAT5 Transcription
Mammary Gland Factor
Mammary Gland Specific Nuclear Factor
Mammary Gland-Specific Nuclear Factor
STAT5 Protein
STAT5a Protein
STAT5a Transcription Factor
STAT5alpha Protein
STAT5b Protein
STAT5b Transcription Factor
STAT5beta Protein
Signal Transducer and Activator of Transcription 5
Signal Transducer and Activator of Transcription 5A
Signal Transducer and Activator of Transcription 5B
Transcription Factor, STAT5
Transcription Factor, STAT5a
Transcription Factor, STAT5b
Tree number(s): D12.644.360.024.342.500
D12.776.157.057.186.500
D12.776.476.024.430.500
D12.776.930.840.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050799
Scope note: A signal transducer and activator of transcription that mediates cellular responses to a variety of CYTOKINES. Stat5 activation is associated with transcription of CELL CYCLE regulators such as CYCLIN KINASE INHIBITOR P21 and anti-apoptotic genes such as BCL-2 GENES. Stat5 is constitutively activated in many patients with acute MYELOID LEUKEMIA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2006; STAT5 PROTEIN was indexed under DNA-BINDING PROTEINS; MILK PROTEINS; & TRANS-ACTIVATORS 1992-2005
History Note: 2006(1992)
DeCS ID: 50798
Unique ID: D050799
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2016/02/18
STAT5 Transcription Factor - Preferred
Concept UI M0420149
Scope note A signal transducer and activator of transcription that mediates cellular responses to a variety of CYTOKINES. Stat5 activation is associated with transcription of CELL CYCLE regulators such as CYCLIN KINASE INHIBITOR P21 and anti-apoptotic genes such as BCL-2 GENES. Stat5 is constitutively activated in many patients with acute MYELOID LEUKEMIA.
Preferred term STAT5 Transcription Factor
Entry term(s) Factor, STAT5 Transcription
STAT5 Protein
Signal Transducer and Activator of Transcription 5
Transcription Factor, STAT5
STAT5b Transcription Factor - Narrower
Concept UI M0204507
Preferred term STAT5b Transcription Factor
Entry term(s) STAT5b Protein
STAT5beta Protein
Signal Transducer and Activator of Transcription 5B
Transcription Factor, STAT5b
STAT5a Transcription Factor - Narrower
Concept UI M0204508
Preferred term STAT5a Transcription Factor
Entry term(s) Mammary Gland Factor
Mammary Gland Specific Nuclear Factor
Mammary Gland-Specific Nuclear Factor
STAT5a Protein
STAT5alpha Protein
Signal Transducer and Activator of Transcription 5A
Transcription Factor, STAT5a



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