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Descriptor English: Complement C3-C5 Convertases
Descriptor Spanish: Convertasas de Complemento C3-C5
Descriptor convertasas del complemento C3-C5
Entry term(s) convertasa C3
convertasa de C3
Scope note: Serina proteasas que escinden el COMPLEMENTO C3 en COMPLEMENTO C3A y COMPLEMENTO C3B, o desdoblan el COMPLEMENTO C5 en COMPLEMENTO C5A y COMPLEMENTO C5B. Incluyen las diferentes formas de convertasas C3/C5 en las vías clásica y alternativa de la ACTIVACIÓN DEL COMPLEMENTO. Ambas escisiones tienen lugar en el extremo C-terminal de un residuo ARGININA.
Descriptor Portuguese: Convertases de Complemento C3-C5
Descriptor French: Complement C3-C5 Convertases
Entry term(s): Activator, C3
C 3 Convertase
C3 Activator
C3 C5 Convertase
C3 Convertase
C3 Convertases, Complement
C3-C5 Convertase
C3-C5 Convertases, Complement
C5 Cleaving Enzyme
C5 Convertase
C5 Convertases, Complement
Complement 3 Convertase
Complement 5 Convertase
Complement C3 C5 Convertases
Complement C3 Convertases
Complement C5 Convertases
Convertase, C 3
Convertase, C3
Convertase, C3-C5
Convertase, Complement 3
Convertases, Complement C3
Convertases, Complement C3-C5
Convertases, Complement C5
Tree number(s): D12.776.124.486.274.045.387
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050577
Scope note: Serine proteases that cleave COMPLEMENT C3 into COMPLEMENT C3A and COMPLEMENT C3B, or cleave COMPLEMENT C5 into COMPLEMENT C5A and COMPLEMENT C5B. These include the different forms of C3/C5 convertases in the classical and the alternative pathways of COMPLEMENT ACTIVATION. Both cleavages take place at the C-terminal of an ARGININE residue.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Registry Number: EC 3.4.21.-
Previous Indexing: Complement C3 (1976-2005)
Complement C5 (1976-2005)
Public MeSH Note: 2006; for COMPLEMENT 3 CONVERTASE see COMPLEMENT 3 CONVERTASE 1991-2005, see COMPLEMENT ACTIVATING ENZYMES 1978-1990
History Note: 2006 (1978)
DeCS ID: 50828
Unique ID: D050577
NLM Classification: QW 680
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2006/07/05
Complement C3-C5 Convertases - Preferred
Concept UI M0476514
Scope note Serine proteases that cleave COMPLEMENT C3 into COMPLEMENT C3A and COMPLEMENT C3B, or cleave COMPLEMENT C5 into COMPLEMENT C5A and COMPLEMENT C5B. These include the different forms of C3/C5 convertases in the classical and the alternative pathways of COMPLEMENT ACTIVATION. Both cleavages take place at the C-terminal of an ARGININE residue.
Preferred term Complement C3-C5 Convertases
Entry term(s) C3 C5 Convertase
C3-C5 Convertase
C3-C5 Convertases, Complement
Complement C3 C5 Convertases
Convertase, C3-C5
Convertases, Complement C3-C5
Complement C3 Convertases - Narrower
Concept UI M0004929
Scope note Serine proteases that cleaves C3 at the carboxyl of Arg-77 of the alpha-chain to yield COMPLEMENT 3A and COMPLEMENT 3B in either the classical or the alternative pathways of COMPLEMENT ACTIVATION.
Preferred term Complement C3 Convertases
Entry term(s) Activator, C3
C 3 Convertase
C3 Activator
C3 Convertase
C3 Convertases, Complement
Complement 3 Convertase
Convertase, C 3
Convertase, C3
Convertase, Complement 3
Convertases, Complement C3
Complement C5 Convertases - Narrower
Concept UI M0476516
Scope note Serine proteases that cleaves C5 at the carboxyl of Arg-74 of the alpha-chain to yield COMPLEMENT 5A and COMPLEMENT 5B in either the classical or the alternative pathways of COMPLEMENT ACTIVATION.
Preferred term Complement C5 Convertases
Entry term(s) C5 Cleaving Enzyme
C5 Convertase
C5 Convertases, Complement
Complement 5 Convertase
Convertases, Complement C5



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