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Descriptor English: Complement Factor D
Descriptor Spanish: Factor D del Complemento
Descriptor Portuguese: Fator D do Complemento
Descriptor French: Facteur D du complément
Entry term(s): 28 kDa Protein, Adipocyte
Activator, C3 Convertase
Adipsin
C3 Convertase Activator
C3 Proactivator Convertase
C3PA Convertase
C3PAse
Complement D Component
Complement Protein D
Convertase Activator, C3
Convertase, C3 Proactivator
Convertase, C3PA
Convertase, Proactivator
D Component of Complement
Factor D
Factor D, Complement
Factor D, Properdin
GBGase
Proactivator Convertase
Properdin Factor D
Protein D, Complement
Tree number(s): D08.811.277.300.450
D08.811.277.656.300.760.200
D08.811.277.656.959.350.200
D12.776.124.486.274.045.450
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011416
Scope note: A serum protein which is important in the ALTERNATIVE COMPLEMENT ACTIVATION PATHWAY. This enzyme cleaves the COMPLEMENT C3B-bound COMPLEMENT FACTOR B to form C3bBb which is ALTERNATIVE PATHWAY C3 CONVERTASE.
Annotation: see SCR for organism-specific terms
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Registry Number: EC 3.4.21.46
Previous Indexing: Enzyme Precursors (1966-1977)
Properdin (1966-1977)
Serum Globulins (1970-1977)
Public MeSH Note: 1999; see PROPERDIN FACTOR D 1991-1998, see COMPLEMENT ACTIVATING ENZYMES 1978-1990; ADIPSIN was indexed under SERINE ENDOPEPTIDASES 1987-2005
History Note: 1999 (1978)
DeCS ID: 23520
Unique ID: D011416
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1977/05/20
Revision Date: 2009/07/06
Complement Factor D - Preferred
Concept UI M0017753
Scope note A serum protein which is important in the ALTERNATIVE COMPLEMENT ACTIVATION PATHWAY. This enzyme cleaves the COMPLEMENT C3B-bound COMPLEMENT FACTOR B to form C3bBb which is ALTERNATIVE PATHWAY C3 CONVERTASE.
Preferred term Complement Factor D
Entry term(s) 28 kDa Protein, Adipocyte
Activator, C3 Convertase
Adipsin
C3 Convertase Activator
C3 Proactivator Convertase
C3PA Convertase
C3PAse
Complement D Component
Complement Protein D
Convertase Activator, C3
Convertase, C3 Proactivator
Convertase, C3PA
Convertase, Proactivator
D Component of Complement
Factor D
Factor D, Complement
Factor D, Properdin
GBGase
Proactivator Convertase
Properdin Factor D
Protein D, Complement



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