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Descriptor English: gamma-Synuclein
Descriptor Spanish: gamma-Sinucleína
Descriptor sinucleína gamma
Entry term(s) gamma-sinucleína
Scope note: Homólogo de la ALFA-SINUCLEÍNA que interviene en la integridad de la red de neurofilamentos. Se encuentra sobreexpresada en diversas NEOPLASIAS humanas y puede que esté relacionada con la modulación de la arquitectura del AXON durante el DESARROLLO EMBRIONARIO y en el adulto. La sinucleína gamma también puede activar las VÍAS DE TRANSDUCCIÓN DE SEÑALES asociadas con la PROTEÍNA ELK-1 CON DOMINIO ETS.
Descriptor Portuguese: gama-Sinucleína
Descriptor French: gamma-Synucléine
Entry term(s): Persyn
Synoretin
gamma Synuclein
Tree number(s): D12.776.631.860.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D051845
Scope note: A homolog of ALPHA-SYNUCLEIN that plays a role in neurofilament network integrity. It is overexpressed in a variety of human NEOPLASMS and may be involved in modulating AXON architecture during EMBRYONIC DEVELOPMENT and in the adult. Gamma-Synuclein may also activate SIGNAL TRANSDUCTION PATHWAYS associated with ETS-DOMAIN PROTEIN ELK-1.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2006; GAMMA-SYNUCLEIN was indexed under NERVE TISSUE PROTEINS 1988-2005
History Note: 2006(1988)
DeCS ID: 51168
Unique ID: D051845
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2015/11/23
gamma-Synuclein - Preferred
Concept UI M0159752
Scope note A homolog of ALPHA-SYNUCLEIN that plays a role in neurofilament network integrity. It is overexpressed in a variety of human NEOPLASMS and may be involved in modulating AXON architecture during EMBRYONIC DEVELOPMENT and in the adult. Gamma-Synuclein may also activate SIGNAL TRANSDUCTION PATHWAYS associated with ETS-DOMAIN PROTEIN ELK-1.
Preferred term gamma-Synuclein
Entry term(s) Persyn
Synoretin
gamma Synuclein



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