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Descriptor English: Apolipoprotein E2
Descriptor Spanish: Apolipoproteína E2
Descriptor apolipoproteína E2
Scope note: Una de las tres isoformas principales de la apolipoproteína E. En los humanos, la Apo E2 difiere de la APOLIPOPROTEÍNA E3 en el residuo 158 en el que la arginina está sustituida por cisteína (R158--C). En contraste con la Apo E3, la Apo E2 exhibe una afinidad extraordinariamente baja para los receptores de LDL (RECEPTORES DE LDL) que median en la internalización y catabolismo de las partículas lipoproteicas en los hepatocitos. La homocigosidad alélica de la ApoE2 se asocia con HIPERLIPOPROTEINEMIA DE TIPO III.
Descriptor Portuguese: Apolipoproteína E2
Descriptor French: Apolipoprotéine E2
Entry term(s): APOE epsilon 2
APOE epsilon2
APOE-epsilon 2
APOE-epsilon2
Apo E 2
Apo E-2
Apo E2
ApoE2
Apolipoprotein E 2
Apolipoprotein E epsilon2
Apolipoprotein E-2
Apolipoprotein E-epsilon2
Tree number(s): D10.532.091.500.249
D12.776.070.400.500.249
D12.776.521.120.500.249
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053329
Scope note: One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Apolipoproteins E (1984-2006)
Public MeSH Note: 2007; APOLIPOPROTEIN E-2 was indexed under APOLIPOPROTEINS E 1985-2006 & under APOLIPOPROTEINS 1984
History Note: 2007 (1984)
DeCS ID: 52266
Unique ID: D053329
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Apolipoprotein E2 - Preferred
Concept UI M0119983
Scope note One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.
Preferred term Apolipoprotein E2
Entry term(s) APOE epsilon 2
APOE epsilon2
APOE-epsilon 2
APOE-epsilon2
Apo E 2
Apo E-2
Apo E2
ApoE2
Apolipoprotein E 2
Apolipoprotein E epsilon2
Apolipoprotein E-2
Apolipoprotein E-epsilon2



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