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Descriptor English: Apolipoprotein E4
Descriptor Spanish: Apolipoproteína E4
Descriptor apolipoproteína E4
Scope note: Isoforma principal y la segunda en frecuencia de la apolipoproteína E. En humanos, la Apo E4 se diferencia de la APOLIPOPROTEÍNA E3 en sólo el residuo 112 (cisteína sustituida por arginina), y exhibe una menor resistencia a la desnaturalización y una mayor propensión a formar intermedios plegados. La Apo E4 es un factor de riesgo de la ENFERMEDAD DE ALZHEIMER y de ENFERMEDADES CARDIOVASCULARES.
Descriptor Portuguese: Apolipoproteína E4
Descriptor French: Apolipoprotéine E4
Entry term(s): Apo E 4
Apo E epsilon 4
Apo E-4
Apo E4
ApoE4
Apolipoprotein E 4
Apolipoprotein E-4
Tree number(s): D10.532.091.500.750
D12.776.070.400.500.750
D12.776.521.120.500.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053327
Scope note: A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Apolipoproteins E (1982-2006)
Public MeSH Note: 2007; APOLIPOPROTEIN E-4 was indexed under APOLIPOPROTEINS E 1985-2006 & under APOLIPPROTEINS 1982-1984
History Note: 2007 (1982)
DeCS ID: 52268
Unique ID: D053327
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Apolipoprotein E4 - Preferred
Concept UI M0108562
Scope note A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.
Preferred term Apolipoprotein E4
Entry term(s) Apo E 4
Apo E epsilon 4
Apo E-4
Apo E4
ApoE4
Apolipoprotein E 4
Apolipoprotein E-4



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