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Descriptor English: Interleukin-1alpha
Descriptor Spanish: Interleucina-1alfa
Descriptor interleucina 1alfa
Entry term(s) IL-1 alfa
Scope note: Subtipo de interleucina-1 que se da como forma de proproteína unida a la membrana que es desdoblada por proteasas para formar una forma madura segregada. A diferencia de la INTERLEUCINA-1BETA, las dos formas de interleucina-1alfa, la unida a la membrana y la segregada, son biológicamente activas.
Descriptor Portuguese: Interleucina-1alfa
Descriptor French: Interleukine-1 alpha
Entry term(s): Hematopoietin 1
Hematopoietin-1
IL-1 alpha
Interleukin 1 alpha
Interleukin 1alpha
Interleukin-1 alpha
Tree number(s): D12.644.276.374.465.010.300
D12.644.276.374.500.400.300
D12.776.467.374.465.010.300
D12.776.467.374.500.400.300
D23.529.374.465.131.300
D23.529.374.500.400.300
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053582
Scope note: An interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form. Unlike INTERLEUKIN-1BETA both membrane-bound and secreted forms of interleukin-1alpha are biologically active.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Interleukin-1 (1988-2006)
Public MeSH Note: 2007; see INTERLEUKIN-1 1988-2006; for HEMATOPOIETIN-1 see HEMATOPOIETIC CELL GROWTH FACTORS 1990-2006
History Note: 2007(1988)
Entry Version: IL 1ALPHA
DeCS ID: 52276
Unique ID: D053582
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2015/04/15
Interleukin-1alpha - Preferred
Concept UI M0011501
Scope note An interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form. Unlike INTERLEUKIN-1BETA both membrane-bound and secreted forms of interleukin-1alpha are biologically active.
Preferred term Interleukin-1alpha
Entry term(s) Hematopoietin 1
Hematopoietin-1
IL-1 alpha
Interleukin 1 alpha
Interleukin 1alpha
Interleukin-1 alpha



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