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Descriptor English: Interleukin-1
Descriptor Spanish: Interleucina-1
Descriptor interleucina 1
Entry term(s) IL-1
factor activador de linfocitos
Scope note: Factor soluble producido por los MONOCITOS, MACRÓFAGOS y otras células que activan los linfocitos T y potencia su respuesta a mitógenos o antígenos. La interleucina 1 es un término general que hace referencia a una de las dos proteínas distintas, INTERLEUCINA 1ALFA e INTERLEUCINA 1BETA. Los efectos biológicos de la IL-1 incluyen la capacidad para sustituir los requerimientos de los macrófagos para la activación de las células T.
Descriptor Portuguese: Interleucina-1
Descriptor French: Interleukine-1
Entry term(s): Epidermal Cell Derived Thymocyte Activating Factor
Epidermal Cell Derived Thymocyte-Activating Factor
IL-1
Interleukin 1
Interleukin I
Lymphocyte Activating Factor
Lymphocyte-Activating Factor
Macrophage Cell Factor
T Helper Factor
Tree number(s): D12.644.276.374.465.010
D12.644.276.374.500.400
D12.776.467.374.465.010
D12.776.467.374.500.400
D23.529.374.465.131
D23.529.374.500.400
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007375
Scope note: A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Lymphocyte Transformation (1972-1982)
Lymphocytes (1966-1971)
Lymphokines (1974-1982)
Macrophages (1966-1982)
Toxins (1966-1973)
Public MeSH Note: 1990; see INTERLEUKIN 1 1983-1989
History Note: 1990(1983)
Related: Receptors, Interleukin-1 MeSH
DeCS ID: 29487
Unique ID: D007375
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1983/01/01
Date of Entry: 1982/04/29
Revision Date: 2015/04/15
Interleukin-1 - Preferred
Concept UI M0011503
Scope note A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
Preferred term Interleukin-1
Entry term(s) Epidermal Cell Derived Thymocyte Activating Factor
Epidermal Cell Derived Thymocyte-Activating Factor
IL-1
Interleukin 1
Interleukin I
Lymphocyte Activating Factor
Lymphocyte-Activating Factor
Macrophage Cell Factor
T Helper Factor



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