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Descriptor English: Ribonuclease H, Human Immunodeficiency Virus
Descriptor Spanish: Ribonucleasa H del Virus de la Inmunodeficiencia Humana
Descriptor ribonucleasa H del virus de la inmunodeficiencia humana
Scope note: Actividad ribonucleásica que es componente de la TRANSCRIPTASA INVERSA DEL VIH. Elimina la hebra del ARN del heterodúplex ARN-ADN producido por transcripción inversa. Una vez eliminada la parte de ARN, puede sintetizarse una copia de ADN bicatenario del ARN del VIH.
Descriptor Portuguese: Ribonuclease H do Vírus da Imunodeficiência Humana
Descriptor French: Ribonucléase H du virus de l'immunodéficience humaine
Entry term(s): HIV RNAse H
HIV Ribonuclease H
RNAse H, HIV
Ribonuclease H, HIV
Tree number(s): D08.811.277.352.355.350.700.500
D08.811.277.352.700.350.700.500
D12.776.964.775.375.545.875.500
D12.776.964.775.562.764.875.500
D12.776.964.900.750.500.545.875.500
D12.776.964.900.750.500.750.187.500
D12.776.964.970.600.850.375.545.875.500
D12.776.964.970.600.850.375.750.187.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D054309
Scope note: A ribonuclease activity that is a component of the HIV REVERSE TRANSCRIPTASE. It removes the RNA strand of the RNA-DNA heteroduplex produced by reverse transcription. Once the RNA moiety is removed a double stranded DNA copy of the HIV RNA can be synthesized.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.26.4
Previous Indexing: Ribonuclease H (1987-2007)
Public MeSH Note: 2008
History Note: 2008
DeCS ID: 52675
Unique ID: D054309
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2013/07/08
Ribonuclease H, Human Immunodeficiency Virus - Preferred
Concept UI M0503935
Scope note A ribonuclease activity that is a component of the HIV REVERSE TRANSCRIPTASE. It removes the RNA strand of the RNA-DNA heteroduplex produced by reverse transcription. Once the RNA moiety is removed a double stranded DNA copy of the HIV RNA can be synthesized.
Preferred term Ribonuclease H, Human Immunodeficiency Virus
Entry term(s) HIV RNAse H
HIV Ribonuclease H
RNAse H, HIV
Ribonuclease H, HIV



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