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Descriptor English: Thyrotropin Alfa
Descriptor Spanish: Tirotropina Alfa
Descriptor tirotropina alfa
Scope note: Forma de glicoproteína recombinante altamente purificada de la HORMONA ESTIMULANTE DE LA TIROIDES humana producida mediante tecnología de ADN recombinante que comprende dos subunidades unidas de forma no covalente, una subunidad alfa de 92 residuos de aminoácidos que contiene dos sitios de N-glucosilación y una subunidad beta de 118 residuos que contiene un sitio de N-glucosilación. La secuencia de aminoácidos de la tirotropina alfa es idéntica a la de la hormona estimulante de la tiroides pituitaria humana.
Descriptor Portuguese: Tirotropina Alfa
Descriptor French: Thyrotropine alfa
Entry term(s): Alfa, Thyrotropin
Human TSH, Recombinant
Recombinant Human TSH
TSH, Recombinant Human
Thyrogen
rhTSH
Tree number(s): D06.472.699.631.525.883.374
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D057073
Scope note: A highly purified recombinant glycoprotein form of human THYROID-STIMULATING HORMONE, produced by recombinant DNA technology comprising two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites, and a beta subunit of 118 residues containing one N-linked glycosylation site. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Glycoprotein Hormones, alpha Subunit (1991-2009)
Public MeSH Note: 2010
History Note: 2010
DeCS ID: 53578
Unique ID: D057073
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2016/07/01
Thyrotropin Alfa - Preferred
Concept UI M0534260
Scope note A highly purified recombinant glycoprotein form of human THYROID-STIMULATING HORMONE, produced by recombinant DNA technology comprising two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites, and a beta subunit of 118 residues containing one N-linked glycosylation site. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.
Preferred term Thyrotropin Alfa
Entry term(s) Alfa, Thyrotropin
Human TSH, Recombinant
Recombinant Human TSH
TSH, Recombinant Human
rhTSH
Thyrogen - Narrower
Concept UI M0534261
Preferred term Thyrogen



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