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Descriptor English: Ataxin-3
Descriptor Spanish: Ataxina-3
Descriptor ataxina -3
Scope note: Enzima desubicuitinizante de la familia de las ATAXINAS. Interviene en la homeostasis proteica, la TRANSCRIPCIÓN GENÉTICA, la regulación del CITOESQUELETO y la MIOGÉNESIS. La EXPANSIÓN DE REPETICIONES DE TRINUCLEÓTIDOS CAG en la región codificante del gen de la ataxina-3 se asocia a la ataxia espinocerebelosa de tipo 3 (ENFERMEDAD DE MACHADO-JOSEPH).
Descriptor Portuguese: Ataxina-3
Descriptor French: Ataxine-3
Entry term(s): ATXN3 Protein
Ataxin 3
Ataxin 3 Protein
Ataxin-3 Protein
Machado Joseph Disease Protein
Machado-Joseph Disease Protein
SCA3 Protein
Spinocerebellar Ataxia 3 Protein
Tree number(s): D08.811.037.250
D12.776.631.069.875
D12.776.660.075.875
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000067699
Scope note: A deubiquitinating enzyme of the ATAXINS family. It functions in protein homeostasis, GENETIC TRANSCRIPTION; CYTOSKELETON regulation, and MYOGENESIS. CAG TRINUCLEOTIDE REPEAT EXPANSION in the Ataxin-3 gene coding region is associated with spinocerebellar ataxia-3 (MACHADO-JOSEPH DISEASE).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.19.12
Previous Indexing: Nerve Tissue Proteins (1998-2015)
Nuclear Proteins (1998-2015)
Proteins (1995-1997)
Public MeSH Note: 2016; ATAXIN-3 was indexed under NERVE TISSUE PROTEINS AND NUCLEAR PROTEINS 1998-2015, and under PROTEINS 1995-1997
History Note: 2016 (1995)
Related: Spinocerebellar Ataxias MeSH
DeCS ID: 55958
Unique ID: D000067699
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2016/01/01
Date of Entry: 2015/07/06
Revision Date: 2016/05/27
Ataxin-3 - Preferred
Concept UI M000600684
Scope note A deubiquitinating enzyme of the ATAXINS family. It functions in protein homeostasis, GENETIC TRANSCRIPTION; CYTOSKELETON regulation, and MYOGENESIS. CAG TRINUCLEOTIDE REPEAT EXPANSION in the Ataxin-3 gene coding region is associated with spinocerebellar ataxia-3 (MACHADO-JOSEPH DISEASE).
Preferred term Ataxin-3
Entry term(s) ATXN3 Protein
Ataxin 3
Ataxin 3 Protein
Ataxin-3 Protein
Machado Joseph Disease Protein
Machado-Joseph Disease Protein
SCA3 Protein
Spinocerebellar Ataxia 3 Protein



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