| Descriptor English: | Deubiquitinating Enzyme CYLD | ||||||
| Descriptor Spanish: |
Enzima Desubiquitinante CYLD
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| Descriptor Portuguese: | Enzima Desubiquitinante CYLD | ||||||
| Descriptor French: | Deubiquitinating enzyme CYLD | ||||||
| Entry term(s): |
CYLD Protein CYLD, Deubiquitinating Enzyme Cylindromatosis Protein Cylindromatosis, Deubiquitinating Enzyme Deubiquitinating Enzyme Cylindromatosis |
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| Tree number(s): |
D08.811.037.375 D12.776.624.776.482 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000074749 | ||||||
| Scope note: | A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 3.4.19.12 | ||||||
| Previous Indexing: |
Tumor Suppressor Proteins (2001-2017) |
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| Public MeSH Note: | 2018 |
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| History Note: | 2018 |
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| DeCS ID: | 56989 | ||||||
| Unique ID: | D000074749 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/06/02 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Deubiquitinating Enzyme CYLD
- Preferred
| Concept UI |
M000627388 |
| Scope note | A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS. |
| Preferred term | Deubiquitinating Enzyme CYLD |
| Entry term(s) |
CYLD Protein CYLD, Deubiquitinating Enzyme Cylindromatosis Protein Cylindromatosis, Deubiquitinating Enzyme Deubiquitinating Enzyme Cylindromatosis |
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