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Descriptor English: Glycogen Synthase Kinase 3 beta
Descriptor Spanish: Glucógeno Sintasa Quinasa 3 beta
Descriptor glucógeno sintasa cinasa 3 beta
Entry term(s) GSK-3beta
GSK3beta
glucógeno sintasa quinasa 3 beta
proteína GSK3B
Scope note: Enzima del tipo de la glucógeno sintasa quinasa-3 que interviene en el METABOLISMO ENERGÉTICO, el DESARROLLO EMBRIONARIO y la NEUROGÉNESIS. También está implicada en la BIOSÍNTESIS DE PROTEÍNAS y regula el crecimiento y proliferación celular como componente de la VÍA DE SEÑALIZACIÓN WNT y otras vías de señalización. Ciertos polimorfismos del gen GSK3B se han asociado a la ENFERMEDAD DE PARKINSON, la ENFERMEDAD DE ALZHEIMER y el TRASTORNO BIPOLAR.
Descriptor Portuguese: Glicogênio Sintase Quinase 3 beta
Descriptor French: Glycogen synthase kinase 3 beta
Entry term(s): GSK 3beta
GSK-3beta
GSK3B Protein
GSK3beta
Tree number(s): D05.500.117.875.500
D08.811.913.696.620.682.700.429.500.500
D08.811.913.696.620.682.700.646.625.500
D12.776.476.081.875.500
D12.776.476.563.429.500.500
D12.776.476.563.646.625.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071679
Scope note: A glycogen synthase kinase-3 type enzyme that functions in ENERGY METABOLISM; EMBRYONIC DEVELOPMENT; and NEUROGENESIS. It is also involved in PROTEIN BIOSYNTHESIS and regulates cell growth and proliferation as a component of the WNT SIGNALING PATHWAY and other signaling pathways. Certain polymorphisms in the GSK3B gene have been associated with PARKINSON DISEASE; ALZHEIMER DISEASE; and BIPOLAR DISORDER.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.11.1
Public MeSH Note: 2017; GLYCOGEN SYNTHASE KINASE 3 BETA was indexed under GLYCOGEN SYNTHASE KINASE 3 2002-2016
History Note: 2017 (2002)
DeCS ID: 56432
Unique ID: D000071679
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/04/15
Glycogen Synthase Kinase 3 beta - Preferred
Concept UI M0143052
Scope note A glycogen synthase kinase-3 type enzyme that functions in ENERGY METABOLISM; EMBRYONIC DEVELOPMENT; and NEUROGENESIS. It is also involved in PROTEIN BIOSYNTHESIS and regulates cell growth and proliferation as a component of the WNT SIGNALING PATHWAY and other signaling pathways. Certain polymorphisms in the GSK3B gene have been associated with PARKINSON DISEASE; ALZHEIMER DISEASE; and BIPOLAR DISORDER.
Preferred term Glycogen Synthase Kinase 3 beta
Entry term(s) GSK 3beta
GSK-3beta
GSK3B Protein
GSK3beta



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