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Descriptor English: Axin Signaling Complex
Descriptor Spanish: Complejo de Señalización de la Axina
Descriptor Portuguese: Complexo de Sinalização da Axina
Descriptor French: Complexe de signalisation de l'axine
Entry term(s): Axin Signaling Complex Proteins
Destruction Complex, beta-Catenin
Signaling Complex, Axin
beta Catenin Destruction Complex
beta-Catenin Destruction Complex
Tree number(s): D05.500.117
D12.776.476.081
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D060465
Scope note: A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2012
History Note: 2012
DeCS ID: 54555
Unique ID: D060465
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2012/01/01
Date of Entry: 2011/06/24
Axin Signaling Complex - Preferred
Concept UI M0554162
Scope note A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.
Preferred term Axin Signaling Complex
Entry term(s) Axin Signaling Complex Proteins
Destruction Complex, beta-Catenin
Signaling Complex, Axin
beta Catenin Destruction Complex
beta-Catenin Destruction Complex



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