| Descriptor English: | Axin Signaling Complex | ||||||
| Descriptor Spanish: |
Complejo de Señalización de la Axina
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| Descriptor Portuguese: | Complexo de Sinalização da Axina | ||||||
| Descriptor French: | Complexe de signalisation de l'axine | ||||||
| Entry term(s): |
Axin Signaling Complex Proteins Destruction Complex, beta-Catenin Signaling Complex, Axin beta Catenin Destruction Complex beta-Catenin Destruction Complex |
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| Tree number(s): |
D05.500.117 D12.776.476.081 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D060465 | ||||||
| Scope note: | A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Public MeSH Note: | 2012 |
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| History Note: | 2012 |
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| DeCS ID: | 54555 | ||||||
| Unique ID: | D060465 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2012/01/01 | ||||||
| Date of Entry: | 2011/06/24 |
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CHEMICALS AND DRUGS
Macromolecular Substances [D05]Macromolecular Substances -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Axin Signaling Complex
- Preferred
| Concept UI |
M0554162 |
| Scope note | A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription. |
| Preferred term | Axin Signaling Complex |
| Entry term(s) |
Axin Signaling Complex Proteins Destruction Complex, beta-Catenin Signaling Complex, Axin beta Catenin Destruction Complex beta-Catenin Destruction Complex |
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