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Descriptor English: Soluble Guanylyl Cyclase
Descriptor Spanish: Guanilil Ciclasa Soluble
Descriptor guanilil ciclasa soluble
Entry term(s) guanilato ciclasa soluble
guanilil ciclasa sensible a óxido nítrico
receptor de óxido nítrico
receptores de óxido nítrico
subunidad alfa de la guanilil ciclasa soluble
subunidad beta de la guanilil ciclasa soluble
Scope note: Enzima de mamíferos formada por un heterodímero de una subunidad alfa y otra beta. Cada subunidad tiene cuatro dominios, domino HNOX N-terminal, dominio tipo PAS, un dominio superenrollado y un dominio catalítico C-terminal. Los cuatro dominios son proteínas homólogas con una conformación similar de los dominios funcionales. La guanilil ciclasa soluble cataliza la formación de GMP cíclico a partir de GTP y es una enzima clave en la vía de señalización por óxido nítrico que participa en muchos procesos biológicos y fisiológicos en mamíferos.
Descriptor Portuguese: Guanilil Ciclase Solúvel
Descriptor French: Soluble guanylyl cyclase
Entry term(s): Cyclase, Soluble Guanylate
Cyclase, Soluble Guanylyl
Guanylate Cyclase, Soluble
Guanylyl Cyclase, Soluble
Nitric Oxide Receptor
Nitric Oxide Receptors
Nitric Oxide Sensitive Guanylyl Cyclase
Nitric Oxide-Sensitive Guanylyl Cyclase
Oxide Receptor, Nitric
Oxide Receptors, Nitric
Receptor, Nitric Oxide
Soluble Guanylate Cyclase
Soluble Guanylyl Cyclase, alpha Subunit
Soluble Guanylyl Cyclase, beta Subunit
Tree number(s): D08.811.520.650.600.750
D12.776.476.350.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071756
Scope note: A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 4.6.1.2
Public MeSH Note: 2017; SOLUBLE GUANYLYL CYCLASE was indexed under GUANYLATE CYCLASE and RECEPTORS, CYTOPLASMIC AND NUCLEAR 2001-2016
History Note: 2017 (2016)
DeCS ID: 56499
Unique ID: D000071756
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2017/06/20
Soluble Guanylyl Cyclase - Preferred
Concept UI M0400048
Scope note A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.
Preferred term Soluble Guanylyl Cyclase
Entry term(s) Cyclase, Soluble Guanylate
Cyclase, Soluble Guanylyl
Guanylate Cyclase, Soluble
Guanylyl Cyclase, Soluble
Nitric Oxide Receptor
Nitric Oxide Receptors
Nitric Oxide Sensitive Guanylyl Cyclase
Nitric Oxide-Sensitive Guanylyl Cyclase
Oxide Receptor, Nitric
Oxide Receptors, Nitric
Receptor, Nitric Oxide
Soluble Guanylate Cyclase
Soluble Guanylyl Cyclase, alpha Subunit - Narrower
Concept UI M000617713
Preferred term Soluble Guanylyl Cyclase, alpha Subunit
Soluble Guanylyl Cyclase, beta Subunit - Narrower
Concept UI M000617714
Preferred term Soluble Guanylyl Cyclase, beta Subunit



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