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Descriptor English: Poly (ADP-Ribose) Polymerase-1
Descriptor Spanish: Poli(ADP-Ribosa) Polimerasa-1
Descriptor poli(ADP-ribosa) polimerasa-1
Entry term(s) NAD+ ADP-ribosiltransferasa-1
NAD+ADP ribosiltransferasa-1
poli (ADP-ribosa) polimerasa-1
poli (ADP-ribosa) sintasa-1
poli ADP-ribosa polimerasa-1
poli ADP-ribosa sintasa-1
poli(ADP-ribosa) sintasa-1
proteína PARP-1
proteína PARP1
Scope note: Poli (ADP-ribosa) polimerasa que contiene dos DEDOS DE ZINC en su región N-terminal de unión al ADN. Modifica las PROTEÍNAS NUCLEARES que participan en la arquitectura de la cromatina y en la REPARACIÓN DEL ADN por excisión de bases con POLI ADENOSINA DIFOSFATO RIBOSA.
Descriptor Portuguese: Poli(ADP-Ribose) Polimerase-1
Descriptor French: Poly (ADP-Ribose) polymerase-1
Entry term(s): NAD+ ADP ribosyltransferase 1
NAD+ ADP-ribosyltransferase-1
PARP 1 Protein
PARP-1 Protein
PARP1 Protein
Poly (ADP-Ribose) Synthase-1
Tree number(s): D08.811.913.400.725.115.690.420
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071137
Scope note: A poly(ADP-ribose) polymerase that contains two ZINC FINGERS in its N-terminal DNA-binding region. It modifies NUCLEAR PROTEINS involved in chromatin architecture and BASE EXCISION REPAIR with POLY ADENOSINE DIPHOSPHATE RIBOSE.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.4.2.30
Previous Indexing: ADP Ribose Transferases (2006-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56505
Unique ID: D000071137
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/02/26
Poly (ADP-Ribose) Polymerase-1 - Preferred
Concept UI M000613201
Scope note A poly(ADP-ribose) polymerase that contains two ZINC FINGERS in its N-terminal DNA-binding region. It modifies NUCLEAR PROTEINS involved in chromatin architecture and BASE EXCISION REPAIR with POLY ADENOSINE DIPHOSPHATE RIBOSE.
Preferred term Poly (ADP-Ribose) Polymerase-1
Entry term(s) NAD+ ADP ribosyltransferase 1
NAD+ ADP-ribosyltransferase-1
PARP 1 Protein
PARP-1 Protein
PARP1 Protein
Poly (ADP-Ribose) Synthase-1



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