Descriptor English: | DEAD Box Protein 58 | ||||||
Descriptor Spanish: |
Proteína 58 DEAD Box
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Descriptor Portuguese: | Proteína DEAD-box 58 | ||||||
Descriptor French: | Protéine-58 à domaine DEAD | ||||||
Entry term(s): |
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 Probable ATP Dependent RNA Helicase DDX58 Probable ATP-Dependent RNA Helicase DDX58 RIG I like Receptor 1 RIG-I-like Receptor 1 |
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Tree number(s): |
D08.811.913.696.445.735.720.249.750 |
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RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000071457 | ||||||
Scope note: | A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length). |
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Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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Registry Number: | EC 3.6.4.13 | ||||||
Previous Indexing: |
DEAD-box RNA Helicases (2006-2016) |
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Public MeSH Note: | 2017 |
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History Note: | 2017 |
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DeCS ID: | 56506 | ||||||
Unique ID: | D000071457 | ||||||
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
Date Established: | 2017/01/01 | ||||||
Date of Entry: | 2016/07/08 | ||||||
Revision Date: | 2016/04/15 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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DEAD Box Protein 58
- Preferred
Concept UI |
M000614788 |
Scope note | A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length). |
Preferred term | DEAD Box Protein 58 |
Entry term(s) |
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 Probable ATP Dependent RNA Helicase DDX58 Probable ATP-Dependent RNA Helicase DDX58 RIG I like Receptor 1 RIG-I-like Receptor 1 |
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