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Descriptor English: DEAD Box Protein 58
Descriptor Spanish: Proteína 58 DEAD Box
Descriptor proteína 58 DEAD Box
Entry term(s) polipéptido 58 caja DEAD (Asp-Glu-Ala-Asp)
probable ARN helicasa DDX58 dependiente de ATP
receptor 1 tipo RIG-I
Scope note: ARN helicasa con caja DEAD que contiene un DOMINIO SIMILAR A DEATH N-terminal, un dominio AAA+ ATPasa y actividad ARN HELICASA C-terminal. Actúa como receptor inmunitario innato mediante el reconocimiento de los ácidos nucleicos víricos. También induce la expresión de INTERFERÓN TIPO I y de CITOQUINAS proinflamatorias. Sus ligandos incluyen: ARN de cadena simple trifosforilado, ARN DE CADENA DOBLE (dsRNA) y dsRNA corto (longitud inferior a 1kb).
Descriptor Portuguese: Proteína DEAD-box 58
Descriptor French: Protéine-58 à domaine DEAD
Entry term(s): DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58
Probable ATP Dependent RNA Helicase DDX58
Probable ATP-Dependent RNA Helicase DDX58
RIG I like Receptor 1
RIG-I-like Receptor 1
Tree number(s): D08.811.913.696.445.735.720.249.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071457
Scope note: A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.6.4.13
Previous Indexing: DEAD-box RNA Helicases (2006-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56506
Unique ID: D000071457
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/04/15
DEAD Box Protein 58 - Preferred
Concept UI M000614788
Scope note A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).
Preferred term DEAD Box Protein 58
Entry term(s) DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58
Probable ATP Dependent RNA Helicase DDX58
Probable ATP-Dependent RNA Helicase DDX58
RIG I like Receptor 1
RIG-I-like Receptor 1



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