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Descriptor English: Interferon-Induced Helicase, IFIH1
Descriptor Spanish: Helicasa Inducida por Interferón IFIH1
Descriptor helicasa inducida por interferón IFIH1
Entry term(s) autoantígeno CADM-140
helicard
interferón inducido con el dominio C de la helicasa 1
proteína 1 que contiene el dominio C de la helicasa inducida por interferón
proteína 1 que contiene el dominio C inducido por interferón de la helicasa
proteína 5 asociada a la diferenciación del melanoma
proteína IFIH1
Scope note: Helicasa del ARN con caja DEAD que contiene dos DOMINIOS DE ACTIVACIÓN DE CASPASA Y RECLUTAMIENTO N-terminales. Actúa como sensor de los ÁCIDOS NUCLEICOS víricos, como el ARN DE CADENA DOBLE, y activa la RESPUESTA INMUNITARIA INNATA mediante la inducción de la expresión de INTERFERÓN-ALFA e INTERFERÓN-BETA. También puede regular el crecimiento celular y la APOPTOSIS.
Descriptor Portuguese: Helicase IFIH1 Induzida por Interferon
Descriptor French: Hélicase IFIH1 inductrice de l'interféron
Entry term(s): Autoantigen, CADM-140
CADM 140 Autoantigen
CADM-140 Autoantigen
Helicard
Helicase, IFIH1 Interferon-Induced
IFIH1 Interferon-Induced Helicase
IFIH1 Protein
Interferon Induced Helicase C Domain Containing Protein 1
Interferon Induced Helicase, IFIH1
Interferon Induced with Helicase C Domain 1
Interferon-Induced Helicase C Domain-Containing Protein 1
Melanoma Differentiation Associated Protein 5
Melanoma Differentiation-Associated Protein 5
Tree number(s): D08.811.913.696.445.735.720.249.875
D12.776.066.125
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000072640
Scope note: A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such as DOUBLE-STRANDED RNA and activates the INNATE IMMUNE RESPONSE by inducing the expression of INTERFERON-ALPHA and INTERFERON-BETA. It may also regulate cell growth and APOPTOSIS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.6.4.13
Previous Indexing: DEAD-box RNA Helicases (2006-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56507
Unique ID: D000072640
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/07/01
Interferon-Induced Helicase, IFIH1 - Preferred
Concept UI M000617674
Scope note A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such as DOUBLE-STRANDED RNA and activates the INNATE IMMUNE RESPONSE by inducing the expression of INTERFERON-ALPHA and INTERFERON-BETA. It may also regulate cell growth and APOPTOSIS.
Preferred term Interferon-Induced Helicase, IFIH1
Entry term(s) Autoantigen, CADM-140
CADM 140 Autoantigen
CADM-140 Autoantigen
Helicard
Helicase, IFIH1 Interferon-Induced
IFIH1 Interferon-Induced Helicase
IFIH1 Protein
Interferon Induced Helicase C Domain Containing Protein 1
Interferon Induced Helicase, IFIH1
Interferon Induced with Helicase C Domain 1
Interferon-Induced Helicase C Domain-Containing Protein 1
Melanoma Differentiation Associated Protein 5
Melanoma Differentiation-Associated Protein 5



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