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Descriptor English: Lumican
Descriptor Spanish: Lumican
Descriptor lumican
Entry term(s) Proteoglicano Lumican
proteoglucano lumican
Scope note: Pequeño proteoglucano que contiene 10 repeticiones de leucina en tándem y 4 sitios de unión-N dentro de la región de repeticiones de leucina que pueden ser sustituidos por QUERATÁN SULFATO. Estas propiedades y su forma en herradura le permiten mediar interacciones entre las moléculas de COLÁGENO y las fibrillas. Se expresa en la mayoría de los tejidos mesenquimatosos y en la CÓRNEA donde actúa manteniendo su transparencia.
Descriptor Portuguese: Lumicana
Descriptor French: Lumicane
Entry term(s): Lumican Proteoglycan
Tree number(s): D09.400.430.930.875.750
D09.698.735.700.875
D12.776.395.650.875.750
D12.776.860.300.806.875
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071234
Scope note: A small leucine-rich proteoglycan that contains 10 tandem leucine repeats and four N-linked sites within the leucine repeat region that may be substituted with KERATAN SULFATE. These properties and its horseshoe shape allow it to mediate interactions among COLLAGEN molecules within fibrils. It is expressed in most mesenchymal tissues as well as the CORNEA, where it functions to maintain transparency.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2017; LUMICAN was indexed under KERATAN SULFATE and CHONDROITIN SULFATE PROTEOGLYCANS 1981-2016, and under KERATAN SULFATE/ANALOGS 1978-1981
History Note: 2017 (1978)
DeCS ID: 56524
Unique ID: D000071234
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/02/26
Lumican - Preferred
Concept UI M0087653
Scope note A small leucine-rich proteoglycan that contains 10 tandem leucine repeats and four N-linked sites within the leucine repeat region that may be substituted with KERATAN SULFATE. These properties and its horseshoe shape allow it to mediate interactions among COLLAGEN molecules within fibrils. It is expressed in most mesenchymal tissues as well as the CORNEA, where it functions to maintain transparency.
Preferred term Lumican
Entry term(s) Lumican Proteoglycan



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