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Descriptor English: Trefoil Factor-2
Descriptor Spanish: Factor Trefoil-2
Descriptor factor trefoil-2
Entry term(s) proteína TFF2
péptido TFF2
Scope note: Factor trifólico de 106 aminoácidos que contiene dos dominios trifolio. Se asocia a la MUCINA 6. Es expresado en el TRACTO GASTROINTESTINAL por las células de las GLÁNDULAS DE BRÜNNER, GLÁNDULAS PILÓRICAS y las células mucosas del cuello. Inhibe la MOTILIDAD GASTROINTESTINAL y la secreción del ÁCIDO GÁSTRICO y puede ayudar a mantener la integridad estructural del moco gástrico.
Descriptor Portuguese: Fator Trefoil-2
Descriptor French: Facteur en trèfle-2
Entry term(s): TFF2 Peptide
TFF2 Protein
Trefoil Factor 2
Tree number(s): D12.644.937.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071164
Scope note: A 106 amino acid (12 kDa) trefoil factor that contains two trefoil domains and associates with MUCIN-6. It is expressed in the GASTROINTESTINAL TRACT by cells of BRUNNER GLANDS; PYLORIC GLANDS and mucous neck cells. It inhibits GASTROINTESTINAL MOTILITY and GASTRIC ACID secretion and may help maintain the structural integrity of gastric mucus.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Public MeSH Note: 2017; TREFOIL FACTOR-2 was indexed under PEPTIDES 2005-2016; under MUCINS 1992-2005; under MUSCLE PROTEINS 1992-2005; and under GROWTH SUBSTANCES 1992-2003
History Note: 2017 (1992)
DeCS ID: 56554
Unique ID: D000071164
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/02/26
Trefoil Factor-2 - Preferred
Concept UI M000613342
Scope note A 106 amino acid (12 kDa) trefoil factor that contains two trefoil domains and associates with MUCIN-6. It is expressed in the GASTROINTESTINAL TRACT by cells of BRUNNER GLANDS; PYLORIC GLANDS and mucous neck cells. It inhibits GASTROINTESTINAL MOTILITY and GASTRIC ACID secretion and may help maintain the structural integrity of gastric mucus.
Preferred term Trefoil Factor-2
Entry term(s) TFF2 Peptide
TFF2 Protein
Trefoil Factor 2



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