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Descriptor English: ERG1 Potassium Channel
Descriptor Spanish: Canal de Potasio ERG1
Descriptor canal de potasio ERG1
Entry term(s) canal de potasio Kv11.1
canal de potasio activado por voltaje, subfamilia H, miembro 2
canal de potasio relacionado a éter-a-go-go
Scope note: Uno de los tres miembros de la familia de genes de los CANALES DE POTASIO éter-a-go-go (EAG) que consta de las subfamilias de genes éter-a-go-go (eag), parecidos a eag (eag-like, elk) y relacionados con eag (eag-related, erg). El gen relacionado con éter-a-go-go 1 (ERG1), también conocido como KCNH2, codifica la subunidad formadora de poro de un canal de potasio rectificador retardado de rápida activación que desempeña un papel esencial en la repolarización final del potencial de acción ventricular. Las mutaciones con pérdida de función en el gen hERG1 humano se asocian a ARRITMIA potencialmente mortal.
Descriptor Portuguese: Canal de Potássio ERG1
Descriptor French: Canal potassique ERG1
Entry term(s): Channel, ERG1 Potassium
Channel, Kv11.1 Protein-Potassium
Ether A Go Go Related Potassium Channel 1
Ether-A-Go-Go-Related Potassium Channel 1
Kv11.1 Protein Potassium Channel
Kv11.1 Protein-Potassium Channel
Potassium Channel, ERG1
Potassium Voltage-Gated Channel, Subfamily H, Member 2
Protein-Potassium Channel, Kv11.1
Tree number(s): D12.776.157.530.400.600.900.249.500
D12.776.543.550.450.750.900.249.500
D12.776.543.585.400.750.900.249.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000072237
Scope note: One of three members of the ether-a-go-go (EAG) POTASSIUM CHANNELS gene family comprising ether-a-go-go (eag), eag-like (elk) and eag-related (erg) subfamilies. Ether-a-go-go-related gene 1 (ERG1) also known as KCNH2, encodes the pore-forming subunit of a rapidly activating-delayed rectifier potassium channel that plays an essential role in the final repolarization of ventricular action potential. Loss-of-function mutations in human hERG1 is associated with life-threatening ARRHYTHMIA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Public MeSH Note: 2017; ERG1 POTASSIUM CHANNEL was indexed under POTASSIUM CHANNELS, VOLTAGE-GATED 2005-2008, and under ETHER-A-GO-GO POTASSIUM CHANNELS 2009-2016
History Note: 2017 (2001)
DeCS ID: 56585
Unique ID: D000072237
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/07/05
ERG1 Potassium Channel - Preferred
Concept UI M0386712
Scope note One of three members of the ether-a-go-go (EAG) POTASSIUM CHANNELS gene family comprising ether-a-go-go (eag), eag-like (elk) and eag-related (erg) subfamilies. Ether-a-go-go-related gene 1 (ERG1) also known as KCNH2, encodes the pore-forming subunit of a rapidly activating-delayed rectifier potassium channel that plays an essential role in the final repolarization of ventricular action potential. Loss-of-function mutations in human hERG1 is associated with life-threatening ARRHYTHMIA.
Preferred term ERG1 Potassium Channel
Entry term(s) Channel, ERG1 Potassium
Ether A Go Go Related Potassium Channel 1
Ether-A-Go-Go-Related Potassium Channel 1
Potassium Channel, ERG1
Potassium Voltage-Gated Channel, Subfamily H, Member 2
Kv11.1 Protein-Potassium Channel - Narrower
Concept UI M000619285
Preferred term Kv11.1 Protein-Potassium Channel
Entry term(s) Channel, Kv11.1 Protein-Potassium
Kv11.1 Protein Potassium Channel
Protein-Potassium Channel, Kv11.1



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