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Descriptor English: Connexin 26
Descriptor Spanish: Conexina 26
Descriptor conexina 26
Entry term(s) conexina Cx26
conexina beta-2
proteína beta-2 de la unión en hendidura
Scope note: Proteína de la unión comunicante codificada por el gen Gap Junction Beta 2 o GJB2. En la cóclea y en la epidermis sus hexámeros forman canales entre células que se abren para permitir la difusión de célula a célula de moléculas pequeñas así como el reciclaje del potasio. Las mutaciones en la conexina 26 se asocian a PÉRDIDA AUDITIVA NEUROSENSORIAL.
Descriptor Portuguese: Conexina 26
Descriptor French: Connexine-26
Entry term(s): 26, Connexin
Connexin Cx26
Connexin beta 2
Connexin beta-2
Connexin, beta2
Cx26, Connexin
Gap Junction beta 2 protein
Gap Junction beta-2 protein
beta-2, Connexin
beta2 Connexin
Tree number(s): D12.776.543.585.250.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000072259
Scope note: A gap junction protein encoded by the Gap Junction Beta 2 or GJB2 gene. In the cochlea and epidermis, its hexamers form channels between cells that open to allow cell-to-cell diffusion of small molecules as well as recycling of potassium. Mutations in Connexin 26 are associated with congenital SENSORINEURAL HEARING LOSS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 127120-53-0
Public MeSH Note: 2017; CONNEXIN 26 was indexed under CONNEXINS 1993-2016
History Note: 2017 (1993)
DeCS ID: 56638
Unique ID: D000072259
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/07/05
Connexin 26 - Preferred
Concept UI M0220781
Scope note A gap junction protein encoded by the Gap Junction Beta 2 or GJB2 gene. In the cochlea and epidermis, its hexamers form channels between cells that open to allow cell-to-cell diffusion of small molecules as well as recycling of potassium. Mutations in Connexin 26 are associated with congenital SENSORINEURAL HEARING LOSS.
Preferred term Connexin 26
Entry term(s) 26, Connexin
Connexin Cx26
Connexin beta 2
Connexin beta-2
Connexin, beta2
Cx26, Connexin
beta-2, Connexin
beta2 Connexin
Gap Junction beta-2 protein - Narrower
Concept UI M000618780
Preferred term Gap Junction beta-2 protein
Entry term(s) Gap Junction beta 2 protein



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