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Descriptor in English: Neoplasm Proteins
Descriptor in Spanish: Proteínas de Neoplasias
Descriptor in Portuguese: Proteínas de Neoplasias
Descriptor in French: Protéines tumorales
Entry term(s): Proteins, Neoplasm
Tree number(s): D12.776.624
Scope note: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Annotation: IM & coord with specific protein (IM) + specific histol type (IM) + specific organ/neoplasms term (IM); Manual 24.4.4.4
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
See also the descriptors: Antigens, Neoplasm MeSH
Biomarkers, Tumor MeSH
DeCS UI: 9556
Descriptor UI: D009363
Date Established: 1963/01/01
Date of Entry: 1999/01/01
Revision Date: 2015/07/13
Neoplasm Proteins - Preferred
Concept UI M0014578
Scope note Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Preferred term Neoplasm Proteins
Entry term(s) Proteins, Neoplasm



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