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Descriptor English: Neoplasm Proteins
Descriptor Spanish: Proteínas de Neoplasias
Descriptor proteínas de neoplasias
Entry term(s) proteínas de tumores
Scope note: PROTEÍNAS cuya expresión anormal (por exceso o por defecto) se asocia al desarrollo, crecimiento o progresión de las NEOPLASIAS. Algunas proteínas de neoplasias son ANTÍGENOS DE NEOPLASIAS, es decir, inducen una reacción inmune al tumor. Se han caracterizado muchas proteínas de neoplasias, que se utilizan como MARCADORES TUMORALES BIOLÓGICOS, cuando son detectables en células y líquidos corporales, para vigilar la existencia o crecimiento de tumores. La expresión anormal de las PROTEINAS ONCOGÉNICAS está implicada en la transformación neoplásica, mientras que la pérdida de la expresión de las PROTEINAS SUPRESORAS DE TUMOR está relacionada con la pérdida del control del crecimiento y progresión de la neoplasia.
Descriptor Portuguese: Proteínas de Neoplasias
Descriptor French: Protéines tumorales
Entry term(s): Proteins, Neoplasm
Tree number(s): D12.776.624
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009363
Scope note: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Annotation: IM & coord with specific protein (IM) + specific histol type (IM) + specific organ/neoplasms term (IM); Manual 24.4.4.4
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Version: NEOPL PROTEINS
Related: Antigens, Neoplasm MeSH
Biomarkers, Tumor MeSH
DeCS ID: 9556
Unique ID: D009363
NLM Classification: QZ 210
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1963/01/01
Date of Entry: 1999/01/01
Revision Date: 2015/07/13
Neoplasm Proteins - Preferred
Concept UI M0014578
Scope note Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Preferred term Neoplasm Proteins
Entry term(s) Proteins, Neoplasm



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