DeCS

Descriptor English:

CYS2-HIS2 Zinc Fingers

Descriptor Spanish:

Dedos de Zinc CYS2-HIS2

Spanish from Spain

Descriptor	dedos de zinc CYS2-HIS2
Entry term(s)	dedos de zinc C2H2 dedos de zinc CY2HIS2 motivos dedos de zinc CYS2-HIS2
Scope note:	Motivo dedo de zinc de aproximadamente 30 aminoácidos con una secuencia general X2-Cys-X2,4-Cys-X12-His-X3,4,5-His que forma un pliegue simple lámina beta- lámina beta- hélice alfa, estabilizado por los iones de zinc. Reconoce y se une a diversas secuencias del ADN eucariótico y es muy frecuente entre algunas PROTEÍNAS DE UNIÓN A ADN y FACTORES DE TRASCRIPCIÓN con una secuencia concreta.

Descriptor Portuguese:

Dedos de Zinco CYS2-HIS2

Descriptor French:

Doigts de zinc CYS2-HIS2

Entry term(s):

C2H2 Zinc Finger
C2H2 Zinc Fingers
CYS2 HIS2 Zinc Finger Motifs
CYS2 HIS2 Zinc Fingers
CYS2-HIS2 Zinc Finger
CYS2-HIS2 Zinc Finger Motifs
CYS2HIS2 Zinc Finger
CYS2HIS2 Zinc Fingers
Finger, C2H2 Zinc
Finger, CYS2-HIS2 Zinc
Finger, CYS2HIS2 Zinc
Fingers, C2H2 Zinc
Fingers, CYS2-HIS2 Zinc
Fingers, CYS2HIS2 Zinc
Zinc Finger, C2H2
Zinc Finger, CYS2-HIS2
Zinc Finger, CYS2HIS2
Zinc Fingers, C2H2
Zinc Fingers, CYS2-HIS2
Zinc Fingers, CYS2HIS2

Tree number(s):

G02.111.570.820.709.275.500.985.250

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D000070580

Scope note:

A zinc finger motif of approximately 30 amino acids with the general sequence X2-Cys-X2,4-Cys-X12-His-X3,4,5-His that forms a simple beta sheet-beta sheet-alpha helix fold stabilized by zinc ions. It recognizes and binds to a variety of eukaryotic DNA sequences and is very common among sequence-specific DNA BINDING PROTEINS and TRANSCRIPTION FACTORS.

Allowable Qualifiers:

DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects

Previous Indexing:

Amino Acid Sequence (1990-2016)
Zinc Fingers (1991-2016)

Public MeSH Note:

2017

History Note:

2017

DeCS ID:

56735

Unique ID:

D000070580

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents

Date Established:

2017/01/01

Date of Entry:

2016/07/08

Revision Date:

2016/05/09

PHENOMENA AND PROCESSES

Chemical Phenomena [G02]

Chemical Phenomena

Biochemical Phenomena [G02.111]

Biochemical Phenomena

Molecular Structure [G02.111.570]

Molecular Structure

Molecular Conformation [G02.111.570.820]

Molecular Conformation

Protein Conformation [G02.111.570.820.709]

Protein Conformation

Protein Structural Elements [G02.111.570.820.709.275]

Protein Structural Elements

Amino Acid Motifs [G02.111.570.820.709.275.500]

Amino Acid Motifs

Zinc Fingers [G02.111.570.820.709.275.500.985]

Zinc Fingers

CYS2-HIS2 Zinc Fingers [G02.111.570.820.709.275.500.985.250]

CYS2-HIS2 Zinc Fingers

MYND Domains [G02.111.570.820.709.275.500.985.375]

MYND Domains

PHD Zinc Fingers [G02.111.570.820.709.275.500.985.438]

PHD Zinc Fingers

RING Finger Domains [G02.111.570.820.709.275.500.985.500]

RING Finger Domains

CYS2-HIS2 Zinc Fingers - Preferred

Concept UI	M000611017
Scope note	A zinc finger motif of approximately 30 amino acids with the general sequence X2-Cys-X2,4-Cys-X12-His-X3,4,5-His that forms a simple beta sheet-beta sheet-alpha helix fold stabilized by zinc ions. It recognizes and binds to a variety of eukaryotic DNA sequences and is very common among sequence-specific DNA BINDING PROTEINS and TRANSCRIPTION FACTORS.
Preferred term	CYS2-HIS2 Zinc Fingers
Entry term(s)	C2H2 Zinc Finger C2H2 Zinc Fingers CYS2 HIS2 Zinc Finger Motifs CYS2 HIS2 Zinc Fingers CYS2-HIS2 Zinc Finger CYS2-HIS2 Zinc Finger Motifs CYS2HIS2 Zinc Finger CYS2HIS2 Zinc Fingers Finger, C2H2 Zinc Finger, CYS2-HIS2 Zinc Finger, CYS2HIS2 Zinc Fingers, C2H2 Zinc Fingers, CYS2-HIS2 Zinc Fingers, CYS2HIS2 Zinc Zinc Finger, C2H2 Zinc Finger, CYS2-HIS2 Zinc Finger, CYS2HIS2 Zinc Fingers, C2H2 Zinc Fingers, CYS2-HIS2 Zinc Fingers, CYS2HIS2

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