DeCS

Descriptor English:

Copper-Transporting ATPases

Descriptor Spanish:

ATPasas Transportadoras de Cobre

Spanish from Spain

Descriptor	ATPasas transportadoras de cobre
Entry term(s)	ATPasa 1 transportadora de cobre ATPasa 2 transportadora de cobre ATPasa ATP7B de unión a Cu ATPasa alfa transportadora de cobre ATPasa de tipo P transportadora de Cu ATP7B ATPasa de tipo P transportadora de Cu de la enfermedad de Wilson ATPasa pineal específica de la noche ATPasa tipo P de unión al Cu de la enfermedad de Wilson ATPasa transportadora de cobre ATPasa transportadora de cobre alfa ATPasas transportadoras de Cu ATPasas transportadoras de Cu(+) adenosina trifosfatasas transportadoras de cobre adenosina-trifosfatasas transportadoras de cobre bomba de cobre 1 enzima PINA polipéptido beta de ATPasa transportadora de Cu++ (enfermedad de Wilson) polipéptido beta de la ATPasa transportadora de Cu++ (enfermedad de Wilson) proteína ATP7A proteína asociada a la enfermedad de Menkes proteína de la enfermedad de Wilson
Scope note:	ATPasas de tipo P que transportan iones de cobre a través de las membranas en las células procariotas y eucariotas. Contienen un motivo aminoácido conservado CISTEÍNA-HISTIDINA-SERINA (CPx) dentro de sus hélices transmembranarias que actúa en la translocación de cationes y en la activación catalítica, y un motivo N-terminal de unión a cobre, CxxC, que regula la actividad enzimática. Juegan un papel esencial en la homeostasis intracelular del cobre mediante la regulación de la captación, salida y almacenamiento de los iones de cobre, y también en la biosíntesis de las cuproproteínas.

Descriptor Portuguese:

ATPases Transportadoras de Cobre

Descriptor French:

Copper-transporting ATPases

Entry term(s):

ATP7A Protein
ATP7B Cu Binding P Type ATPase
ATP7B Cu-Binding P Type ATPase
ATPase 1, Copper-Transporting
ATPase 2, Copper-Transporting
ATPase Copper Transporting alpha
ATPase, Copper-Transporting
ATPase, Cu++ Transporting, beta Polypeptide (Wilson Disease)
ATPase, Pineal Night-Specific
ATPases, Copper-Transporting
ATPases, Cu-Transporting
Adenosine Triphosphatases, Copper-Transporting
Copper Pump 1
Copper Transporting ATPase
Copper Transporting ATPase 1
Copper Transporting ATPase 2
Copper Transporting ATPases
Copper Transporting Adenosine Triphosphatases
Copper-Transporting ATPase
Copper-Transporting ATPase 1
Copper-Transporting ATPase 2
Copper-Transporting Adenosine Triphosphatases
Cu Transporting ATPases
Cu(+)-Transporting ATPases
Cu-Transporting ATPases
Menkes Disease Associated Protein
Menkes Disease-Associated Protein
Night-Specific ATPase, Pineal
PINA Enzyme
Pineal Night Specific ATPase
Pineal Night-Specific ATPase
Triphosphatases, Copper-Transporting Adenosine
Wilson Disease Cu Binding P Type ATPase
Wilson Disease Cu-Binding P Type ATPase
Wilson Disease Protein

Tree number(s):

D08.811.277.040.025.314.500
D12.776.157.530.450.250.578.750
D12.776.157.530.813.500
D12.776.543.585.450.250.578.750
D12.776.543.585.813.500

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D000073840

Scope note:

P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within their transmembrane helices that functions in cation translocation and catalytic activation, and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play essential roles in intracellular copper homeostasis through regulating the uptake, efflux and storage of copper ions, and in cuproprotein biosynthesis.

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Concept UI	M000624072
Scope note	P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within their transmembrane helices that functions in cation translocation and catalytic activation, and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play essential roles in intracellular copper homeostasis through regulating the uptake, efflux and storage of copper ions, and in cuproprotein biosynthesis.
Preferred term	Copper-Transporting ATPases
Entry term(s)	ATPase, Copper-Transporting ATPases, Copper-Transporting ATPases, Cu-Transporting Adenosine Triphosphatases, Copper-Transporting Copper Transporting ATPase Copper Transporting ATPases Copper Transporting Adenosine Triphosphatases Copper-Transporting ATPase Copper-Transporting Adenosine Triphosphatases Cu Transporting ATPases Cu(+)-Transporting ATPases Cu-Transporting ATPases Triphosphatases, Copper-Transporting Adenosine

Concept UI	M0245720
Preferred term	Wilson Disease Protein
Entry term(s)	ATP7B Cu Binding P Type ATPase ATP7B Cu-Binding P Type ATPase ATPase 2, Copper-Transporting ATPase, Cu++ Transporting, beta Polypeptide (Wilson Disease) Copper Transporting ATPase 2 Copper-Transporting ATPase 2 Wilson Disease Cu Binding P Type ATPase Wilson Disease Cu-Binding P Type ATPase

Concept UI	M000624522
Preferred term	Copper-Transporting ATPase 1
Entry term(s)	ATP7A Protein ATPase 1, Copper-Transporting ATPase Copper Transporting alpha Copper Pump 1 Copper Transporting ATPase 1 Menkes Disease Associated Protein Menkes Disease-Associated Protein

Concept UI	M0245719
Preferred term	Pineal Night-Specific ATPase
Entry term(s)	ATPase, Pineal Night-Specific Night-Specific ATPase, Pineal PINA Enzyme Pineal Night Specific ATPase

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