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Descriptor English: P-type ATPases
Descriptor Spanish: ATPasas Tipo P
Descriptor ATPasas tipo P
Entry term(s) ATPasa tipo P
ATPasas E1-E2
ATPasas tipo fosforilación
adenosina trifosfatasas tipo P
adenosina trifosfatasas tipo fosforilación
adenosina-trifosfatasa de tipo P
Scope note: Familia muy conservada de ATPasas que facilitan el transporte de lípidos y cationes a través de la membrana plasmática. Estructuralmente son HÉLICES ALFA elongadas que constituyen cinco dominios funcionales concretos: tres dominios citoplasmáticos, A, N y P, que contienen los sitios catalíticos, y dos dominios transmembranarios. El dominio N fosforila el dominio P en un residuo ASPARTATO invariable que, a su vez, es desfosforilado por el dominio A. Los ciclos de fosforilación y desfosforilación conducen a cambios conformacionales de la proteína entre dos estados (E1 y E2), lo que permite el acceso del sustrato al otro lado de la membrana.
Descriptor Portuguese: ATPases do Tipo-P
Descriptor French: P-type ATPases
Entry term(s): ATPase, P-type
ATPases, E1-E2
ATPases, P-type
ATPases, Phosphorylation-type
Adenosine Triphosphatase, P-type
Adenosine Triphosphatases, P-type
Adenosine Triphosphatases, Phosphorylation-type
E1 E2 ATPases
E1-E2 ATPases
P type ATPase
P type ATPases
P type Adenosine Triphosphatase
P type Adenosine Triphosphatases
P-type ATPase
P-type Adenosine Triphosphatase
P-type Adenosine Triphosphatases
Phosphorylation type ATPases
Phosphorylation type Adenosine Triphosphatases
Phosphorylation-type ATPases
Phosphorylation-type Adenosine Triphosphatases
Triphosphatase, P-type Adenosine
Triphosphatases, P-type Adenosine
Triphosphatases, Phosphorylation-type Adenosine
Tree number(s): D08.811.277.040.025.314
D12.776.157.530.813
D12.776.543.585.813
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000073779
Scope note: A highly conserved family of ATPases that facilitate the transport of lipids and cations across the plasma membrane. Structurally, they are elongated ALPHA-HELICES constituting five functionally distinct domains: three cytoplasmic domains A, N, and P which contain the catalytic sites, and two transmembrane domains. The N domain phosphorylates the P-domain at an invariant ASPARTATE residue, which, in turn, is dephosphorylated by the A domain. The phosphorylation and dephosphorylation cycles drive conformational changes in the protein between two states (E1 and E2), which allow the substrate to access the other side of the membrane.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.6.3.-
Previous Indexing: Adenosine Triphosphatases (1992-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 56997
Unique ID: D000073779
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2020/05/27
P-type ATPases - Preferred
Concept UI M000623906
Scope note A highly conserved family of ATPases that facilitate the transport of lipids and cations across the plasma membrane. Structurally, they are elongated ALPHA-HELICES constituting five functionally distinct domains: three cytoplasmic domains A, N, and P which contain the catalytic sites, and two transmembrane domains. The N domain phosphorylates the P-domain at an invariant ASPARTATE residue, which, in turn, is dephosphorylated by the A domain. The phosphorylation and dephosphorylation cycles drive conformational changes in the protein between two states (E1 and E2), which allow the substrate to access the other side of the membrane.
Preferred term P-type ATPases
Entry term(s) ATPase, P-type
ATPases, E1-E2
ATPases, P-type
ATPases, Phosphorylation-type
Adenosine Triphosphatase, P-type
Adenosine Triphosphatases, P-type
Adenosine Triphosphatases, Phosphorylation-type
E1 E2 ATPases
E1-E2 ATPases
P type ATPase
P type ATPases
P type Adenosine Triphosphatase
P type Adenosine Triphosphatases
P-type ATPase
P-type Adenosine Triphosphatase
P-type Adenosine Triphosphatases
Phosphorylation type ATPases
Phosphorylation type Adenosine Triphosphatases
Phosphorylation-type ATPases
Phosphorylation-type Adenosine Triphosphatases
Triphosphatase, P-type Adenosine
Triphosphatases, P-type Adenosine
Triphosphatases, Phosphorylation-type Adenosine



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