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Descriptor English: Anoctamins
Descriptor Spanish: Anoctaminas
Descriptor Portuguese: Anoctaminas
Descriptor French: Anoctamines
Entry term(s): Anoctamin
Protein Family, TMEM16
TMEM16 Protein Family
TMEM16 Proteins
Tree number(s): D12.776.157.530.400.175.032
D12.776.543.550.450.175.032
D12.776.543.585.400.175.032
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000075368
Scope note: A family of transmembrane proteins that function primarily as calcium-activated chloride channels. Structurally, they form a homodimer where each subunit consists of eight transmembrane helices with the N and C terminals exposed to the cytosol. The regions between helices 5 and 7 may be important for ion pore formation and calcium ion binding.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Chloride Channels (2009-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57079
Unique ID: D000075368
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/05/24
Anoctamins - Preferred
Concept UI M000630244
Scope note A family of transmembrane proteins that function primarily as calcium-activated chloride channels. Structurally, they form a homodimer where each subunit consists of eight transmembrane helices with the N and C terminals exposed to the cytosol. The regions between helices 5 and 7 may be important for ion pore formation and calcium ion binding.
Preferred term Anoctamins
Entry term(s) Anoctamin
Protein Family, TMEM16
TMEM16 Protein Family
TMEM16 Proteins



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