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Descriptor English: NEDD8 Protein
Descriptor Spanish: Proteína NEDD8
Descriptor proteína NEDD8
Entry term(s) proteína NEDD-8
proteína regulada por el desarrollo y expresada por las células precursoras neuronales 8
proteína tipo ubicuitina NEDD8
Scope note: Proteína similar a ubicuitina que participa en la regulación del CICLO CELULAR y la embriogénesis. Se une de forma covalente a sus sustratos tras la activación por el complejo ENZIMA E1 ACTIVADORA DE UBICUITINA-UBA3. La proteína NEDD8 se une a las CULLINAS para promover, mediante su actividad UBICUITINA-PROTEÍNA LIGASA E3, la poliubicuitinación y degradación de las CICLINAS y de las proteínas reguladoras.
Descriptor Portuguese: Proteína NEDD8
Descriptor French: Protéine NEDD8
Entry term(s): NEDD 8 Protein
NEDD-8 Protein
NEDD8, Ubiquitin-like Protein
Neural Precursor Cell Expressed Developmentally Down Regulated Protein 8
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8
Ubiquitin like Protein NEDD8
Ubiquitin-like Protein NEDD8
Tree number(s): D12.776.947.218
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000075687
Scope note: A ubiquitin-like protein that functions in CELL CYCLE regulation and embryogenesis. It is attached covalently to its substrates following activation by the UBIQUITIN-ACTIVATING ENZYME E1-UBA3 enzyme complex. NEDD8 attaches to CULLINS, activating their E3 UBIQUITIN LIGASE activity, to promote polyubiquitination and degradation of CYCLINS and regulatory proteins
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Ubiquitins (1993-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57143
Unique ID: D000075687
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
NEDD8 Protein - Preferred
Concept UI M000631126
Scope note A ubiquitin-like protein that functions in CELL CYCLE regulation and embryogenesis. It is attached covalently to its substrates following activation by the UBIQUITIN-ACTIVATING ENZYME E1-UBA3 enzyme complex. NEDD8 attaches to CULLINS, activating their E3 UBIQUITIN LIGASE activity, to promote polyubiquitination and degradation of CYCLINS and regulatory proteins
Preferred term NEDD8 Protein
Entry term(s) NEDD 8 Protein
NEDD-8 Protein
NEDD8, Ubiquitin-like Protein
Neural Precursor Cell Expressed Developmentally Down Regulated Protein 8
Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8
Ubiquitin like Protein NEDD8
Ubiquitin-like Protein NEDD8



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