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Descriptor English: Autophagy-Related Protein 12
Descriptor Spanish: Proteína 12 Relacionada con la Autofagia
Descriptor proteína 12 relacionada con la autofagia
Entry term(s) proteína ATG12
proteína ATG12 similar a ubicuitina
proteína ATG12 similar a ubiquitina
Scope note: Proteína modificadora similar a la UBICUITINA que actúa en la formación de los AUTOFAGOSOMAS, en el transporte desde el CITOPLASMA a las VACUOLAS, la DEGRADACIÓN MITOCONDRIAL y la nucleofagia. La conjugación con la PROTEÍNA ATG5 o ATG10 es esencial para su función. El conjugado ATG2-ATG5 actúa como una enzima similar a la UBICUITINA-LIGASA para la modificación lipídica de la FAMILIA DE PROTEÍNAS ATG8 y la localización de éstas en las membranas vesiculares.
Descriptor Portuguese: Proteína 12 Relacionada à Autofagia
Descriptor French: Protéine-12 associée à l'autophagie
Entry term(s): ATG12 Protein
ATG12, Ubiquitin-Like Protein
Autophagy Related Protein 12
Ubiquitin Like Protein ATG12
Ubiquitin-Like Protein ATG12
Tree number(s): D12.776.094.391
D12.776.947.125
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071192
Scope note: A UBIQUITIN-like modifier protein that functions in AUTOPHAGOSOME formation, CYTOPLASM to VACUOLE transport, MITOPHAGY, and nucleophagy. Conjugation with ATG5 PROTEIN or ATG10 is essential for its function. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN LIGASE-like enzyme for lipid modification of ATG8 FAMILY PROTEINS and their localization to vesicle membranes.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Small Ubiquitin-Related Modifier Proteins (2008-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56558
Unique ID: D000071192
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/02/25
Autophagy-Related Protein 12 - Preferred
Concept UI M000613485
Scope note A UBIQUITIN-like modifier protein that functions in AUTOPHAGOSOME formation, CYTOPLASM to VACUOLE transport, MITOPHAGY, and nucleophagy. Conjugation with ATG5 PROTEIN or ATG10 is essential for its function. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN LIGASE-like enzyme for lipid modification of ATG8 FAMILY PROTEINS and their localization to vesicle membranes.
Preferred term Autophagy-Related Protein 12
Entry term(s) ATG12 Protein
ATG12, Ubiquitin-Like Protein
Autophagy Related Protein 12
Ubiquitin Like Protein ATG12
Ubiquitin-Like Protein ATG12



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