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Descriptor English: Irinotecan
Descriptor Spanish: Irinotecán
Descriptor irinotecán
Entry term(s) 7 etil 10 hidroxicamptotecina
7-etil-10-hidroxicamptotecina
CPT 11
CPT-11
CPT11
SN 38
SN 38 11
SN-38
SN-38-11
SN3811
camptosar
camptotecina 11
camptotecina-11
compuesto NK012
hidrocloruro de irinotecán
Scope note: Derivado semisintético de la camptotecina que inhibe las ADN TOPOISOMERASAS DE TIPO I para prevenir la síntesis de ácidos nucleicos durante la FASE S. Se usa como antineoplásico para el tratamiento de las NEOPLASIAS COLORRECTALES y de las NEOPLASIAS PANCREÁTICAS.
Descriptor Portuguese: Irinotecano
Descriptor French: Irinotécan
Entry term(s): 7 Ethyl 10 hydroxycamptothecin
7-Ethyl-10-hydroxycamptothecin
CPT 11
CPT-11
CPT11
Camptosar
Camptothecin 11
Camptothecin-11
Irinotecan Hydrochloride
Irrinotecan
NK012 Compound
SN 38
SN 38 11
SN-38
SN-38-11
SN3811
Tree number(s): D03.132.151.425
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077146
Scope note: A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Topoisomerase I Inhibitors
Registry Number: 7673326042
CAS Type 1 Name: (1,4'-Bipiperidine)-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester
Public MeSH Note: 2019; IRINOTECAN was indexed under CAMPTOTHECIN 1987-2018
History Note: 2019 (1987)
DeCS ID: 57518
Unique ID: D000077146
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/07/02
Irinotecan - Preferred
Concept UI M0147530
Scope note A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS.
Preferred term Irinotecan
Entry term(s) Camptothecin 11
Camptothecin-11
Irrinotecan
SN 38 11 - Narrower
Concept UI M0147527
Preferred term SN 38 11
Entry term(s) SN-38-11
SN3811
SN 38 - Narrower
Concept UI M0147536
Preferred term SN 38
Entry term(s) SN-38
NK012 Compound - Narrower
Concept UI M0519525
Preferred term NK012 Compound
CPT-11 - Narrower
Concept UI M000633158
Preferred term CPT-11
Entry term(s) CPT 11
CPT11
Camptosar - Narrower
Concept UI M0147526
Preferred term Camptosar
7-Ethyl-10-hydroxycamptothecin - Narrower
Concept UI M0147534
Preferred term 7-Ethyl-10-hydroxycamptothecin
Entry term(s) 7 Ethyl 10 hydroxycamptothecin
Irinotecan Hydrochloride - Narrower
Concept UI M0398524
Preferred term Irinotecan Hydrochloride



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