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Descriptor English: Topotecan
Descriptor Spanish: Topotecan
Descriptor Portuguese: Topotecan
Descriptor French: Topotécane
Entry term(s): 9 Dimethylaminomethyl 10 hydroxycamptothecin
9-Dimethylaminomethyl-10-hydroxycamptothecin
Hycamtamine
Hycamtin
Hydrochloride, Nogitecan
Hydrochloride, Topotecan
NSC 609699
NSC-609699
NSC609699
Nogitecan Hydrochloride
SK&F 104864 A
SK&F-104864-A
SK&F104864A
SKF 104864 A
SKF-104864-A
SKF104864A
Topotecan Hydrochloride
Topotecan Monohydrochloride, (S)-Isomer
Tree number(s): D03.132.151.850
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019772
Scope note: An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Topoisomerase I Inhibitors
Registry Number: 7M7YKX2N15
Previous Indexing: Camptothecin/analogs & derivatives (1991-1997)
Public MeSH Note: 98; TOPOTECAN was indexed under CAMPTOTHECIN/analogs & derivatives 1991-97
History Note: 98; use TOPOTECAN (NM) 1991-97
DeCS ID: 33404
Unique ID: D019772
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2017/01/17
Topotecan - Preferred
Concept UI M0029340
Scope note An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.
Preferred term Topotecan
Entry term(s) 9 Dimethylaminomethyl 10 hydroxycamptothecin
9-Dimethylaminomethyl-10-hydroxycamptothecin
Topotecan Hydrochloride - Narrower
Concept UI M0329084
Preferred term Topotecan Hydrochloride
Entry term(s) Hydrochloride, Nogitecan
Hydrochloride, Topotecan
Nogitecan Hydrochloride
Topotecan Monohydrochloride, (S)-Isomer
SK&F-104864-A - Narrower
Concept UI M0352761
Preferred term SK&F-104864-A
Entry term(s) SK&F 104864 A
SK&F104864A
SKF 104864 A
SKF-104864-A
SKF104864A
Hycamtin - Narrower
Concept UI M0352657
Preferred term Hycamtin
NSC-609699 - Narrower
Concept UI M0352658
Preferred term NSC-609699
Entry term(s) NSC 609699
NSC609699
Hycamtamine - Narrower
Concept UI M000623496
Preferred term Hycamtamine



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