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Descriptor English: Camptothecin
Descriptor Spanish: Camptotecina
Descriptor Portuguese: Camptotecina
Descriptor French: Camptothécine
Entry term(s): Camptothecine
Tree number(s): D03.132.151
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002166
Scope note: An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Annotation:
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents, Phytogenic
Topoisomerase I Inhibitors
Registry Number: XT3Z54Z28A
CAS Type 1 Name: 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-
Previous Indexing: Alkaloids (1966-1972)
Antineoplastic Agents (1966-1972)
Public MeSH Note: 73
History Note: 73
DeCS ID: 2198
Unique ID: D002166
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08
Camptothecin - Preferred
Concept UI M0003242
Scope note An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Preferred term Camptothecin
Entry term(s) Camptothecine



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