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Descriptor English: Granulins
Descriptor Spanish: Granulinas
Descriptor granulinas
Entry term(s) epitelina
epitelina 1
epitelina 2
epitelina 3
epitelina 4
epitelina 5
epitelina-1
epitelina-2
epitelina2
epitelinas
granulina
granulina (123-179)
granulina (206-261)
granulina 1
granulina 2
granulina 3
granulina 4
granulina 5
granulina 6
granulina 7
granulina A
granulina B
granulina C
granulina D
granulina E
granulina F
granulina G
granulina-3
granulina3
paragranulina
péptido de granulina (281-336)
péptido de granulina (58 -113)
péptidos de granulina
Scope note: Péptidos de pequeño tamaño ricos en cisteína generados por la escisión proteolítica de la progranulina. Cada péptido de granulina está compuesto de un motivo de granulina, mientras que la paragranulina está compuesta por un motivo de media granulina. Las granulinas de mamíferos se denominan granulina 1-7 por su orden de secuencia en el propéptido de progranulina, y también se denominan granulina G, F, B, A, C, D y E, o epitelina 7, 6, 2, 1, 3, 4 y 5, es decir, granulina 1, también conocida como granulina G, también conocida como epitelina 7, etc.
Descriptor Portuguese: Granulinas
Descriptor French: Granulines
Entry term(s): 5, Granulin
Epithelin
Epithelin 1
Epithelin 2
Epithelin 3
Epithelin 4
Epithelin 5
Epithelin-1
Epithelin-2
Epithelin2
Epithelins
Granulin
Granulin (123-179)
Granulin (206-261)
Granulin 1
Granulin 2
Granulin 3
Granulin 4
Granulin 5
Granulin 6
Granulin 7
Granulin A
Granulin B
Granulin C
Granulin D
Granulin E
Granulin F
Granulin G
Granulin Peptide (281-336)
Granulin Peptide (58 -113)
Granulin Peptides
Granulin-3
Granulin3
Paragranulin
Tree number(s): D06.472.699.682.500
D12.644.276.917.500
D12.776.467.917.500
D23.529.917.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077155
Scope note: Small, cysteine-rich peptides generated by the proteolytic cleavage of progranulin. Granulin peptides are each composed of a granulin-motif, while paragranulin is composed of a half-granulin motif. The mammalian granulins are named granulin 1-7 for their sequence order in the progranulin propeptide, and are alternately named granulin G, F, B, A, C, D, and E; or epithelin 7, 6, 2, 1, 3, 4, and 5, i.e. granulin 1 aka granulin G aka epithelin 7, etc.
Annotation: do not confuse with the viral protein GRANULIN MATRIX PROTEINS see OCCLUSION BODY MATRIX PROTEINS
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Intercellular Signaling Peptides and Proteins (1992-2018)
Public MeSH Note: 2019
History Note: 2019
DeCS ID: 57525
Unique ID: D000077155
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2020/05/27
Granulins - Preferred
Concept UI M000639465
Scope note Small, cysteine-rich peptides generated by the proteolytic cleavage of progranulin. Granulin peptides are each composed of a granulin-motif, while paragranulin is composed of a half-granulin motif. The mammalian granulins are named granulin 1-7 for their sequence order in the progranulin propeptide, and are alternately named granulin G, F, B, A, C, D, and E; or epithelin 7, 6, 2, 1, 3, 4, and 5, i.e. granulin 1 aka granulin G aka epithelin 7, etc.
Preferred term Granulins
Entry term(s) Epithelin
Epithelins
Granulin
Granulin Peptides
Granulin 5 - Narrower
Concept UI M000640456
Scope note Granulin from the fifth granulin repeat of the proteolytically processed mammalian progranulin protein. It is also called granulin C or epithelin 3.
Preferred term Granulin 5
Entry term(s) 5, Granulin
Epithelin 3
Granulin C
Granulin 7 - Narrower
Concept UI M000640457
Scope note Granulin from the seventh granulin repeat of the proteolytically processed mammalian progranulin protein. It is also called granulin E or epithelin 5.
Preferred term Granulin 7
Entry term(s) Epithelin 5
Granulin E
Paragranulin - Narrower
Concept UI M000639467
Scope note A granulin composed of the half granulin repeat.
Preferred term Paragranulin
Granulin 1 - Narrower
Concept UI M0216251
Scope note Granulin from the first granulin repeat of the proteolytically processed mammalian progranulin protein . It is also called Granulin G.
Preferred term Granulin 1
Entry term(s) Granulin G
Granulin Peptide (58 -113)
Granulin 2 - Narrower
Concept UI M0216254
Scope note Granulin from the second granulin repeat of the proteolytically processed mammalian progranulin protein. It is also called granulin F.
Preferred term Granulin 2
Entry term(s) Granulin (123-179)
Granulin F
Granulin 6 - Narrower
Concept UI M000640455
Scope note Granulin from the sixth granulin repeat of the proteolytically processed mammalian progranulin protein. It is also called granulin D or epithelin 4.
Preferred term Granulin 6
Entry term(s) Epithelin 4
Granulin D
Granulin 3 - Narrower
Concept UI M0181725
Scope note Granulin from the third granulin repeat of the proteolytically processed mammalian progranulin protein. It is also called Granulin B.
Preferred term Granulin 3
Entry term(s) Epithelin 2
Epithelin-2
Epithelin2
Granulin (206-261)
Granulin B
Granulin-3
Granulin3
Granulin 4 - Narrower
Concept UI M0181722
Scope note Granulin from the fourth granulin repeat of the proteolytically processed mammalian progranulin protein. It is also called granulin A or epithelin 1.
Preferred term Granulin 4
Entry term(s) Epithelin 1
Epithelin-1
Granulin A
Granulin Peptide (281-336)



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