| Descriptor English: | Progranulins | ||||||
| Descriptor Spanish: |
Progranulinas
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| Descriptor Portuguese: | Progranulinas | ||||||
| Descriptor French: | Progranulines | ||||||
| Entry term(s): |
Acrogranin Granulin Precursor Granulin Precursor Protein PC Cell Derived Growth Factor PC Cell-Derived Growth Factor Proepithelin Progranulin |
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| Tree number(s): |
D06.472.699.682 D12.644.276.917 D12.776.467.917 D12.776.811.703 D23.529.917 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000077153 | ||||||
| Scope note: | Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE. |
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| Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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| Previous Indexing: |
Intercellular Signaling Peptides and Proteins (1999-2018) |
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| Public MeSH Note: | 2019; GRANULIN PRECURSOR PROTEIN was indexed under INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS 2004-2018 and VIRAL PROTEINS1992-2003 |
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| History Note: | 2019 |
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| DeCS ID: | 57523 | ||||||
| Unique ID: | D000077153 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2019/01/01 | ||||||
| Date of Entry: | 2018/07/09 | ||||||
| Revision Date: | 2019/07/05 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors
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Progranulins
- Preferred
| Concept UI |
M000639461 |
| Scope note | Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE. |
| Preferred term | Progranulins |
| Entry term(s) |
Acrogranin Granulin Precursor Granulin Precursor Protein PC Cell Derived Growth Factor PC Cell-Derived Growth Factor Proepithelin Progranulin |
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