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Descriptor English: Eptifibatide
Descriptor Spanish: Eptifibatida
Descriptor eptifibatida
Entry term(s) epifibatida
epifibratida
integrelina
integrilina
ácido (3R,11S,17S,20S,25aS)-3-(aminocarbonil)-11-(4-((aminoiminometil)amino)butil)docosahidro-20-(1H-indol-3-ilmetil)-1,9,12,15,18,21-hexaoxo-7H-pirrolo(2,1-g)(1,2,5,8,11,14,17,20)ditiahexaazaciclotricosina-17-acético
Scope note: Péptido cíclico que actúa como antagonista de la glucoproteína IIB-IIIA de las plaquetas, inhibiendo reversiblemente la unión del FIBRINÓGENO, del FACTOR DE VON WILLEBRAND y de otras moléculas adhesivas a los RECEPTORES GPIIB-IIIA de las plaquetas. Se usa en el tratamiento de la ANGINA INESTABLE y en pacientes que se someten a intervenciones de ANGIOPLASTIA coronaria e implantación de stents.
Descriptor Portuguese: Eptifibatida
Descriptor French: Eptifibatide
Entry term(s): 7H-Pyrrolo(2,1-g)(1,2,5,8,11,14,17,20)dithiahexaazacyclotricosine-17-acetic acid, 3-(aminocarbonyl)-11-(4-((aminoiminomethyl)amino)butyl)docosahydro-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxo-, (3R,11S,17S,20S,25aS)-
Epifibatide
Epifibratide
Integrelin
Integrilin
Tree number(s): D12.644.641.366
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077542
Scope note: Cyclic peptide that acts as a platelet glycoprotein IIB-IIIA antagonist, reversibly inhibiting the binding of FIBRINOGEN; VON WILLEBRAND FACTOR; and other adhesive molecules to the GPIIB-IIIA RECEPTORS of platelets. It is used in the management of UNSTABLE ANGINA and in patients undergoing coronary ANGIOPLASTY and stenting procedures.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Platelet Aggregation Inhibitors
Registry Number: NA8320J834
CAS Type 1 Name: 7H-Pyrrolo(2,1-g)(1,2,5,8,11,14,17,20)dithiahexaazacyclotricosine-17-acetic acid, 3-(aminocarbonyl)-11-(4-((aminoiminomethyl)amino)butyl)docosahydro-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxo-, (3R,11S,17S,20S,25aS)-
Public MeSH Note: 2019; EPTIFIBATIDE was indexed under PEPTIDES 1994-2018
History Note: 2019 (1994)
DeCS ID: 57667
Unique ID: D000077542
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2019/04/29
Eptifibatide - Preferred
Concept UI M0229697
Scope note Cyclic peptide that acts as a platelet glycoprotein IIB-IIIA antagonist, reversibly inhibiting the binding of FIBRINOGEN; VON WILLEBRAND FACTOR; and other adhesive molecules to the GPIIB-IIIA RECEPTORS of platelets. It is used in the management of UNSTABLE ANGINA and in patients undergoing coronary ANGIOPLASTY and stenting procedures.
Preferred term Eptifibatide
Entry term(s) 7H-Pyrrolo(2,1-g)(1,2,5,8,11,14,17,20)dithiahexaazacyclotricosine-17-acetic acid, 3-(aminocarbonyl)-11-(4-((aminoiminomethyl)amino)butyl)docosahydro-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxo-, (3R,11S,17S,20S,25aS)-
Epifibatide
Epifibratide
Integrilin - Narrower
Concept UI M0229698
Preferred term Integrilin
Entry term(s) Integrelin



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